39354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2214976..2215490 Replicon chromosome
Accession NZ_AP024734
Organism Staphylococcus aureus strain 59691

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX19_RS11125 Protein ID WP_000581793.1
Coordinates 2214976..2215185 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX19_RS11130 Protein ID WP_000138932.1
Coordinates 2215197..2215490 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX19_RS11105 (2210485) 2210485..2211843 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX19_RS11110 (2211858) 2211858..2212928 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX19_RS11115 (2213246) 2213246..2214448 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX19_RS11120 (2214711) 2214711..2214848 - 138 WP_000828354.1 Lmo0850 family protein -
OCX19_RS11125 (2214976) 2214976..2215185 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX19_RS11130 (2215197) 2215197..2215490 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX19_RS11135 (2215656) 2215656..2217140 + 1485 WP_000571549.1 cardiolipin synthase -
OCX19_RS11140 (2217168) 2217168..2217815 + 648 WP_001187628.1 HD domain-containing protein -
OCX19_RS11145 (2218429) 2218429..2219301 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX19_RS11150 (2219387) 2219387..2220028 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39354 WP_000581793.1 NZ_AP024734:c2215185-2214976 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39354 NZ_AP024734:c2215185-2214976 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39354 WP_000138932.1 NZ_AP024734:c2215490-2215197 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39354 NZ_AP024734:c2215490-2215197 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References