Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1610478..1611266 Replicon chromosome
Accession NZ_AP024734
Organism Staphylococcus aureus strain 59691

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag OCX19_RS07850 Protein ID WP_000525004.1
Coordinates 1610805..1611266 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag OCX19_RS07845 Protein ID WP_000333630.1
Coordinates 1610478..1610792 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX19_RS07785 (1605620) 1605620..1606786 - 1167 WP_064129389.1 DUF2800 domain-containing protein -
OCX19_RS07790 (1606783) 1606783..1607145 - 363 WP_000985976.1 hypothetical protein -
OCX19_RS07795 (1607160) 1607160..1607483 - 324 WP_000174994.1 hypothetical protein -
OCX19_RS07800 (1607562) 1607562..1607723 - 162 WP_001285963.1 DUF1270 family protein -
OCX19_RS07805 (1607736) 1607736..1607999 - 264 WP_001124159.1 helix-turn-helix domain-containing protein -
OCX19_RS07810 (1608024) 1608024..1608239 - 216 WP_001097552.1 hypothetical protein -
OCX19_RS07815 (1608294) 1608294..1608659 + 366 WP_001128433.1 hypothetical protein -
OCX19_RS07820 (1608628) 1608628..1608873 - 246 WP_001025401.1 DUF2829 domain-containing protein -
OCX19_RS07825 (1608929) 1608929..1609138 + 210 WP_000642492.1 hypothetical protein -
OCX19_RS07830 (1609128) 1609128..1609271 - 144 WP_000939498.1 hypothetical protein -
OCX19_RS07835 (1609300) 1609300..1610076 - 777 WP_001148544.1 Rha family transcriptional regulator -
OCX19_RS07840 (1610090) 1610090..1610326 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
OCX19_RS07845 (1610478) 1610478..1610792 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
OCX19_RS07850 (1610805) 1610805..1611266 + 462 WP_000525004.1 hypothetical protein Toxin
OCX19_RS07855 (1611284) 1611284..1611868 + 585 WP_000825948.1 hypothetical protein -
OCX19_RS07860 (1612098) 1612098..1612244 + 147 WP_072433242.1 hypothetical protein -
OCX19_RS07865 (1612241) 1612241..1612855 - 615 WP_000191466.1 hypothetical protein -
OCX19_RS07870 (1612981) 1612981..1614186 + 1206 WP_000264747.1 site-specific integrase -
OCX19_RS07875 (1614229) 1614229..1616256 - 2028 WP_117219080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1565718..1631813 66095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T39346 WP_000525004.1 NZ_AP024734:1610805-1611266 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T39346 NZ_AP024734:1610805-1611266 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT39346 WP_000333630.1 NZ_AP024734:1610478-1610792 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT39346 NZ_AP024734:1610478-1610792 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References