39342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 847423..847900 Replicon chromosome
Accession NZ_AP024734
Organism Staphylococcus aureus strain 59691

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX19_RS04030 Protein ID WP_000052076.1
Coordinates 847423..847611 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX19_RS04035 Protein ID WP_001059690.1
Coordinates 847640..847900 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX19_RS04000 (843413) 843413..843934 + 522 WP_000824464.1 hypothetical protein -
OCX19_RS04005 (844275) 844275..844961 + 687 WP_117218907.1 thermonuclease family protein -
OCX19_RS04010 (845318) 845318..845518 + 201 WP_001059082.1 cold-shock protein -
OCX19_RS04015 (846014) 846014..846232 - 219 WP_000005886.1 hypothetical protein -
OCX19_RS04020 (846294) 846294..846578 - 285 WP_001004401.1 hypothetical protein -
OCX19_RS04025 (846666) 846666..847235 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX19_RS04030 (847423) 847423..847611 - 189 WP_000052076.1 hypothetical protein Toxin
OCX19_RS04035 (847640) 847640..847900 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX19_RS04040 (848240) 848240..848443 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX19_RS04045 (848440) 848440..848676 - 237 WP_000368687.1 hypothetical protein -
OCX19_RS04050 (848900) 848900..849481 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX19_RS04055 (849554) 849554..850171 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX19_RS04060 (850326) 850326..850820 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX19_RS04065 (851219) 851219..851641 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX19_RS04070 (851789) 851789..852505 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39342 WP_000052076.1 NZ_AP024734:c847611-847423 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39342 NZ_AP024734:c847611-847423 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39342 WP_001059690.1 NZ_AP024734:c847900-847640 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39342 NZ_AP024734:c847900-847640 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References