39334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2156227..2156741 Replicon chromosome
Accession NZ_AP024732
Organism Staphylococcus aureus strain 59621

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX17_RS10715 Protein ID WP_000581793.1
Coordinates 2156227..2156436 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX17_RS10720 Protein ID WP_000138932.1
Coordinates 2156448..2156741 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX17_RS10695 (2151736) 2151736..2153094 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX17_RS10700 (2153109) 2153109..2154179 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX17_RS10705 (2154497) 2154497..2155699 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX17_RS10710 (2155962) 2155962..2156099 - 138 WP_000828354.1 Lmo0850 family protein -
OCX17_RS10715 (2156227) 2156227..2156436 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX17_RS10720 (2156448) 2156448..2156741 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX17_RS10725 (2156907) 2156907..2158391 + 1485 WP_000571549.1 cardiolipin synthase -
OCX17_RS10730 (2158419) 2158419..2159066 + 648 WP_001187628.1 HD domain-containing protein -
OCX17_RS10735 (2159680) 2159680..2160552 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX17_RS10740 (2160638) 2160638..2161279 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39334 WP_000581793.1 NZ_AP024732:c2156436-2156227 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39334 NZ_AP024732:c2156436-2156227 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39334 WP_000138932.1 NZ_AP024732:c2156741-2156448 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39334 NZ_AP024732:c2156741-2156448 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References