Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844347..844824 Replicon chromosome
Accession NZ_AP024732
Organism Staphylococcus aureus strain 59621

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX17_RS04015 Protein ID WP_000052076.1
Coordinates 844347..844535 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX17_RS04020 Protein ID WP_001059690.1
Coordinates 844564..844824 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX17_RS03985 (840337) 840337..840858 + 522 WP_000824464.1 hypothetical protein -
OCX17_RS03990 (841199) 841199..841885 + 687 WP_117218907.1 thermonuclease family protein -
OCX17_RS03995 (842242) 842242..842442 + 201 WP_001059082.1 cold-shock protein -
OCX17_RS04000 (842938) 842938..843156 - 219 WP_000005886.1 hypothetical protein -
OCX17_RS04005 (843218) 843218..843502 - 285 WP_001004401.1 hypothetical protein -
OCX17_RS04010 (843590) 843590..844159 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX17_RS04015 (844347) 844347..844535 - 189 WP_000052076.1 hypothetical protein Toxin
OCX17_RS04020 (844564) 844564..844824 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX17_RS04025 (845164) 845164..845367 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX17_RS04030 (845364) 845364..845600 - 237 WP_000368687.1 hypothetical protein -
OCX17_RS04035 (845824) 845824..846405 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX17_RS04040 (846478) 846478..847095 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX17_RS04045 (847250) 847250..847744 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX17_RS04050 (848143) 848143..848565 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX17_RS04055 (848713) 848713..849429 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39326 WP_000052076.1 NZ_AP024732:c844535-844347 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39326 NZ_AP024732:c844535-844347 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39326 WP_001059690.1 NZ_AP024732:c844824-844564 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39326 NZ_AP024732:c844824-844564 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References