Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1595487..1596275 Replicon chromosome
Accession NZ_AP024730
Organism Staphylococcus aureus strain 59574

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag OCX16_RS07760 Protein ID WP_000525004.1
Coordinates 1595814..1596275 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag OCX16_RS07755 Protein ID WP_000333630.1
Coordinates 1595487..1595801 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX16_RS07695 (1590629) 1590629..1591795 - 1167 WP_064129389.1 DUF2800 domain-containing protein -
OCX16_RS07700 (1591792) 1591792..1592154 - 363 WP_000985976.1 hypothetical protein -
OCX16_RS07705 (1592169) 1592169..1592492 - 324 WP_000174994.1 hypothetical protein -
OCX16_RS07710 (1592571) 1592571..1592732 - 162 WP_001285963.1 DUF1270 family protein -
OCX16_RS07715 (1592745) 1592745..1593008 - 264 WP_001124159.1 helix-turn-helix domain-containing protein -
OCX16_RS07720 (1593033) 1593033..1593248 - 216 WP_001097552.1 hypothetical protein -
OCX16_RS07725 (1593303) 1593303..1593668 + 366 WP_001128433.1 hypothetical protein -
OCX16_RS07730 (1593637) 1593637..1593882 - 246 WP_001025401.1 DUF2829 domain-containing protein -
OCX16_RS07735 (1593938) 1593938..1594147 + 210 WP_000642492.1 hypothetical protein -
OCX16_RS07740 (1594137) 1594137..1594280 - 144 WP_000939498.1 hypothetical protein -
OCX16_RS07745 (1594309) 1594309..1595085 - 777 WP_001148544.1 Rha family transcriptional regulator -
OCX16_RS07750 (1595099) 1595099..1595335 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
OCX16_RS07755 (1595487) 1595487..1595801 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
OCX16_RS07760 (1595814) 1595814..1596275 + 462 WP_000525004.1 hypothetical protein Toxin
OCX16_RS07765 (1596293) 1596293..1596877 + 585 WP_000825948.1 hypothetical protein -
OCX16_RS07770 (1597107) 1597107..1597253 + 147 WP_072433242.1 hypothetical protein -
OCX16_RS07775 (1597250) 1597250..1597864 - 615 WP_000191466.1 hypothetical protein -
OCX16_RS07780 (1597990) 1597990..1599195 + 1206 WP_000264747.1 site-specific integrase -
OCX16_RS07785 (1599238) 1599238..1601265 - 2028 WP_117219080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 1554568..1621778 67210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T39310 WP_000525004.1 NZ_AP024730:1595814-1596275 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T39310 NZ_AP024730:1595814-1596275 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT39310 WP_000333630.1 NZ_AP024730:1595487-1595801 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT39310 NZ_AP024730:1595487-1595801 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References