Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844256..844733 Replicon chromosome
Accession NZ_AP024730
Organism Staphylococcus aureus strain 59574

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX16_RS04005 Protein ID WP_000052076.1
Coordinates 844256..844444 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX16_RS04010 Protein ID WP_001059690.1
Coordinates 844473..844733 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX16_RS03975 (840246) 840246..840767 + 522 WP_000824464.1 hypothetical protein -
OCX16_RS03980 (841108) 841108..841794 + 687 WP_117218907.1 thermonuclease family protein -
OCX16_RS03985 (842151) 842151..842351 + 201 WP_001059082.1 cold-shock protein -
OCX16_RS03990 (842847) 842847..843065 - 219 WP_000005886.1 hypothetical protein -
OCX16_RS03995 (843127) 843127..843411 - 285 WP_001004401.1 hypothetical protein -
OCX16_RS04000 (843499) 843499..844068 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX16_RS04005 (844256) 844256..844444 - 189 WP_000052076.1 hypothetical protein Toxin
OCX16_RS04010 (844473) 844473..844733 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX16_RS04015 (845073) 845073..845276 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX16_RS04020 (845273) 845273..845509 - 237 WP_000368687.1 hypothetical protein -
OCX16_RS04025 (845733) 845733..846314 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX16_RS04030 (846387) 846387..847004 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX16_RS04035 (847159) 847159..847653 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX16_RS04040 (848052) 848052..848474 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX16_RS04045 (848622) 848622..849338 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39306 WP_000052076.1 NZ_AP024730:c844444-844256 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39306 NZ_AP024730:c844444-844256 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39306 WP_001059690.1 NZ_AP024730:c844733-844473 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39306 NZ_AP024730:c844733-844473 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References