Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2160662..2161176 Replicon chromosome
Accession NZ_AP024728
Organism Staphylococcus aureus strain 59553

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX18_RS10705 Protein ID WP_000581793.1
Coordinates 2160662..2160871 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX18_RS10710 Protein ID WP_000138932.1
Coordinates 2160883..2161176 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX18_RS10685 (2156171) 2156171..2157529 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX18_RS10690 (2157544) 2157544..2158614 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX18_RS10695 (2158932) 2158932..2160134 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX18_RS10700 (2160397) 2160397..2160534 - 138 WP_000828354.1 Lmo0850 family protein -
OCX18_RS10705 (2160662) 2160662..2160871 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX18_RS10710 (2160883) 2160883..2161176 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX18_RS10715 (2161342) 2161342..2162826 + 1485 WP_000571549.1 cardiolipin synthase -
OCX18_RS10720 (2162854) 2162854..2163501 + 648 WP_001187628.1 HD domain-containing protein -
OCX18_RS10725 (2164115) 2164115..2164987 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX18_RS10730 (2165073) 2165073..2165714 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39298 WP_000581793.1 NZ_AP024728:c2160871-2160662 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39298 NZ_AP024728:c2160871-2160662 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39298 WP_000138932.1 NZ_AP024728:c2161176-2160883 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39298 NZ_AP024728:c2161176-2160883 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References