Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 846036..846513 | Replicon | chromosome |
Accession | NZ_AP024728 | ||
Organism | Staphylococcus aureus strain 59553 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | OCX18_RS04005 | Protein ID | WP_000052076.1 |
Coordinates | 846036..846224 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | OCX18_RS04010 | Protein ID | WP_001059690.1 |
Coordinates | 846253..846513 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OCX18_RS03975 (842026) | 842026..842547 | + | 522 | WP_000824464.1 | hypothetical protein | - |
OCX18_RS03980 (842888) | 842888..843574 | + | 687 | WP_117218907.1 | thermonuclease family protein | - |
OCX18_RS03985 (843931) | 843931..844131 | + | 201 | WP_001059082.1 | cold-shock protein | - |
OCX18_RS03990 (844627) | 844627..844845 | - | 219 | WP_000005886.1 | hypothetical protein | - |
OCX18_RS03995 (844907) | 844907..845191 | - | 285 | WP_001004401.1 | hypothetical protein | - |
OCX18_RS04000 (845279) | 845279..845848 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
OCX18_RS04005 (846036) | 846036..846224 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
OCX18_RS04010 (846253) | 846253..846513 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
OCX18_RS04015 (846853) | 846853..847056 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
OCX18_RS04020 (847053) | 847053..847289 | - | 237 | WP_000368687.1 | hypothetical protein | - |
OCX18_RS04025 (847513) | 847513..848094 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
OCX18_RS04030 (848167) | 848167..848784 | - | 618 | WP_000255544.1 | LysE/ArgO family amino acid transporter | - |
OCX18_RS04035 (848939) | 848939..849433 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
OCX18_RS04040 (849832) | 849832..850254 | - | 423 | WP_000974464.1 | organic hydroperoxide resistance protein | - |
OCX18_RS04045 (850402) | 850402..851118 | + | 717 | WP_000150012.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T39290 WP_000052076.1 NZ_AP024728:c846224-846036 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T39290 NZ_AP024728:c846224-846036 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT39290 WP_001059690.1 NZ_AP024728:c846513-846253 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT39290 NZ_AP024728:c846513-846253 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |