Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 846036..846513 Replicon chromosome
Accession NZ_AP024728
Organism Staphylococcus aureus strain 59553

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX18_RS04005 Protein ID WP_000052076.1
Coordinates 846036..846224 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX18_RS04010 Protein ID WP_001059690.1
Coordinates 846253..846513 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX18_RS03975 (842026) 842026..842547 + 522 WP_000824464.1 hypothetical protein -
OCX18_RS03980 (842888) 842888..843574 + 687 WP_117218907.1 thermonuclease family protein -
OCX18_RS03985 (843931) 843931..844131 + 201 WP_001059082.1 cold-shock protein -
OCX18_RS03990 (844627) 844627..844845 - 219 WP_000005886.1 hypothetical protein -
OCX18_RS03995 (844907) 844907..845191 - 285 WP_001004401.1 hypothetical protein -
OCX18_RS04000 (845279) 845279..845848 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX18_RS04005 (846036) 846036..846224 - 189 WP_000052076.1 hypothetical protein Toxin
OCX18_RS04010 (846253) 846253..846513 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX18_RS04015 (846853) 846853..847056 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX18_RS04020 (847053) 847053..847289 - 237 WP_000368687.1 hypothetical protein -
OCX18_RS04025 (847513) 847513..848094 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX18_RS04030 (848167) 848167..848784 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX18_RS04035 (848939) 848939..849433 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX18_RS04040 (849832) 849832..850254 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX18_RS04045 (850402) 850402..851118 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39290 WP_000052076.1 NZ_AP024728:c846224-846036 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39290 NZ_AP024728:c846224-846036 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39290 WP_001059690.1 NZ_AP024728:c846513-846253 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39290 NZ_AP024728:c846513-846253 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References