Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2185427..2185941 Replicon chromosome
Accession NZ_AP024726
Organism Staphylococcus aureus strain 59482

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX11_RS10945 Protein ID WP_000581793.1
Coordinates 2185427..2185636 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX11_RS10950 Protein ID WP_000138932.1
Coordinates 2185648..2185941 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX11_RS10925 (2180936) 2180936..2182294 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX11_RS10930 (2182309) 2182309..2183379 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX11_RS10935 (2183697) 2183697..2184899 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX11_RS10940 (2185162) 2185162..2185299 - 138 WP_000828354.1 Lmo0850 family protein -
OCX11_RS10945 (2185427) 2185427..2185636 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX11_RS10950 (2185648) 2185648..2185941 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX11_RS10955 (2186107) 2186107..2187591 + 1485 WP_000571549.1 cardiolipin synthase -
OCX11_RS10960 (2187619) 2187619..2188266 + 648 WP_001187628.1 HD domain-containing protein -
OCX11_RS10965 (2188880) 2188880..2189752 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX11_RS10970 (2189838) 2189838..2190479 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39283 WP_000581793.1 NZ_AP024726:c2185636-2185427 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39283 NZ_AP024726:c2185636-2185427 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39283 WP_000138932.1 NZ_AP024726:c2185941-2185648 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39283 NZ_AP024726:c2185941-2185648 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References