Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1586364..1587152 Replicon chromosome
Accession NZ_AP024726
Organism Staphylococcus aureus strain 59482

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag OCX11_RS07730 Protein ID WP_000525004.1
Coordinates 1586691..1587152 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag OCX11_RS07725 Protein ID WP_000333630.1
Coordinates 1586364..1586678 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX11_RS07665 (1581506) 1581506..1582672 - 1167 WP_064129389.1 DUF2800 domain-containing protein -
OCX11_RS07670 (1582669) 1582669..1583031 - 363 WP_000985976.1 hypothetical protein -
OCX11_RS07675 (1583046) 1583046..1583369 - 324 WP_000174994.1 hypothetical protein -
OCX11_RS07680 (1583448) 1583448..1583609 - 162 WP_001285963.1 DUF1270 family protein -
OCX11_RS07685 (1583622) 1583622..1583885 - 264 WP_001124159.1 helix-turn-helix domain-containing protein -
OCX11_RS07690 (1583910) 1583910..1584125 - 216 WP_001097552.1 hypothetical protein -
OCX11_RS07695 (1584180) 1584180..1584545 + 366 WP_001128433.1 hypothetical protein -
OCX11_RS07700 (1584514) 1584514..1584759 - 246 WP_001025401.1 DUF2829 domain-containing protein -
OCX11_RS07705 (1584815) 1584815..1585024 + 210 WP_000642492.1 hypothetical protein -
OCX11_RS07710 (1585014) 1585014..1585157 - 144 WP_000939498.1 hypothetical protein -
OCX11_RS07715 (1585186) 1585186..1585962 - 777 WP_001148544.1 Rha family transcriptional regulator -
OCX11_RS07720 (1585976) 1585976..1586212 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
OCX11_RS07725 (1586364) 1586364..1586678 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
OCX11_RS07730 (1586691) 1586691..1587152 + 462 WP_000525004.1 hypothetical protein Toxin
OCX11_RS07735 (1587170) 1587170..1587754 + 585 WP_000825948.1 hypothetical protein -
OCX11_RS07740 (1587984) 1587984..1588130 + 147 WP_072433242.1 hypothetical protein -
OCX11_RS07745 (1588127) 1588127..1588741 - 615 WP_000191466.1 hypothetical protein -
OCX11_RS07750 (1588867) 1588867..1590072 + 1206 WP_000264747.1 site-specific integrase -
OCX11_RS07755 (1590115) 1590115..1592142 - 2028 WP_117219080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1544546..1609392 64846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T39275 WP_000525004.1 NZ_AP024726:1586691-1587152 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T39275 NZ_AP024726:1586691-1587152 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT39275 WP_000333630.1 NZ_AP024726:1586364-1586678 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT39275 NZ_AP024726:1586364-1586678 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References