Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 839860..840337 Replicon chromosome
Accession NZ_AP024726
Organism Staphylococcus aureus strain 59482

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX11_RS04000 Protein ID WP_000052076.1
Coordinates 839860..840048 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX11_RS04005 Protein ID WP_001059690.1
Coordinates 840077..840337 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX11_RS03970 (835850) 835850..836371 + 522 WP_000824464.1 hypothetical protein -
OCX11_RS03975 (836712) 836712..837398 + 687 WP_117218907.1 thermonuclease family protein -
OCX11_RS03980 (837755) 837755..837955 + 201 WP_001059082.1 cold-shock protein -
OCX11_RS03985 (838451) 838451..838669 - 219 WP_000005886.1 hypothetical protein -
OCX11_RS03990 (838731) 838731..839015 - 285 WP_001004401.1 hypothetical protein -
OCX11_RS03995 (839103) 839103..839672 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX11_RS04000 (839860) 839860..840048 - 189 WP_000052076.1 hypothetical protein Toxin
OCX11_RS04005 (840077) 840077..840337 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX11_RS04010 (840677) 840677..840880 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX11_RS04015 (840877) 840877..841113 - 237 WP_000368687.1 hypothetical protein -
OCX11_RS04020 (841337) 841337..841918 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX11_RS04025 (841991) 841991..842608 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX11_RS04030 (842763) 842763..843257 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX11_RS04035 (843656) 843656..844078 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX11_RS04040 (844226) 844226..844942 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39271 WP_000052076.1 NZ_AP024726:c840048-839860 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39271 NZ_AP024726:c840048-839860 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39271 WP_001059690.1 NZ_AP024726:c840337-840077 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39271 NZ_AP024726:c840337-840077 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References