Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2202788..2203302 Replicon chromosome
Accession NZ_AP024723
Organism Staphylococcus aureus strain 59458

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag OCX22_RS11010 Protein ID WP_000581793.1
Coordinates 2202788..2202997 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag OCX22_RS11015 Protein ID WP_000138932.1
Coordinates 2203009..2203302 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX22_RS10990 (2198297) 2198297..2199655 - 1359 WP_261921370.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
OCX22_RS10995 (2199670) 2199670..2200740 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
OCX22_RS11000 (2201058) 2201058..2202260 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
OCX22_RS11005 (2202523) 2202523..2202660 - 138 WP_000828354.1 Lmo0850 family protein -
OCX22_RS11010 (2202788) 2202788..2202997 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
OCX22_RS11015 (2203009) 2203009..2203302 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
OCX22_RS11020 (2203468) 2203468..2204952 + 1485 WP_000571549.1 cardiolipin synthase -
OCX22_RS11025 (2204980) 2204980..2205627 + 648 WP_001187628.1 HD domain-containing protein -
OCX22_RS11030 (2206241) 2206241..2207113 - 873 WP_000725802.1 membrane protein insertase YidC -
OCX22_RS11035 (2207199) 2207199..2207840 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T39263 WP_000581793.1 NZ_AP024723:c2202997-2202788 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T39263 NZ_AP024723:c2202997-2202788 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT39263 WP_000138932.1 NZ_AP024723:c2203302-2203009 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT39263 NZ_AP024723:c2203302-2203009 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References