Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1597663..1598451 Replicon chromosome
Accession NZ_AP024723
Organism Staphylococcus aureus strain 59458

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag OCX22_RS07775 Protein ID WP_000525004.1
Coordinates 1597990..1598451 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag OCX22_RS07770 Protein ID WP_000333630.1
Coordinates 1597663..1597977 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX22_RS07710 (1592805) 1592805..1593971 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
OCX22_RS07715 (1593968) 1593968..1594330 - 363 WP_000985984.1 hypothetical protein -
OCX22_RS07720 (1594345) 1594345..1594668 - 324 WP_000175001.1 hypothetical protein -
OCX22_RS07725 (1594747) 1594747..1594908 - 162 WP_001285954.1 DUF1270 domain-containing protein -
OCX22_RS07730 (1594921) 1594921..1595184 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
OCX22_RS07735 (1595209) 1595209..1595424 - 216 WP_001097552.1 hypothetical protein -
OCX22_RS07740 (1595479) 1595479..1595844 + 366 WP_001128433.1 hypothetical protein -
OCX22_RS07745 (1595813) 1595813..1596058 - 246 WP_001025401.1 DUF2829 domain-containing protein -
OCX22_RS07750 (1596114) 1596114..1596323 + 210 WP_000642492.1 hypothetical protein -
OCX22_RS07755 (1596313) 1596313..1596456 - 144 WP_000939498.1 hypothetical protein -
OCX22_RS07760 (1596485) 1596485..1597261 - 777 WP_001148544.1 Rha family transcriptional regulator -
OCX22_RS07765 (1597275) 1597275..1597511 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
OCX22_RS07770 (1597663) 1597663..1597977 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
OCX22_RS07775 (1597990) 1597990..1598451 + 462 WP_000525004.1 hypothetical protein Toxin
OCX22_RS07780 (1598469) 1598469..1599053 + 585 WP_000825948.1 hypothetical protein -
OCX22_RS07785 (1599283) 1599283..1599429 + 147 WP_261921362.1 hypothetical protein -
OCX22_RS07790 (1599426) 1599426..1600040 - 615 WP_000191459.1 hypothetical protein -
OCX22_RS07795 (1600166) 1600166..1601371 + 1206 WP_031864865.1 site-specific integrase -
OCX22_RS07800 (1601414) 1601414..1603441 - 2028 WP_001793477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1553277..1618998 65721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T39255 WP_000525004.1 NZ_AP024723:1597990-1598451 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T39255 NZ_AP024723:1597990-1598451 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT39255 WP_000333630.1 NZ_AP024723:1597663-1597977 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT39255 NZ_AP024723:1597663-1597977 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References