Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849721..850198 Replicon chromosome
Accession NZ_AP024723
Organism Staphylococcus aureus strain 59458

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag OCX22_RS04025 Protein ID WP_000052076.1
Coordinates 849721..849909 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag OCX22_RS04030 Protein ID WP_001059690.1
Coordinates 849938..850198 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX22_RS03995 (845711) 845711..846232 + 522 WP_000824464.1 hypothetical protein -
OCX22_RS04000 (846573) 846573..847259 + 687 WP_117218907.1 thermonuclease family protein -
OCX22_RS04005 (847616) 847616..847816 + 201 WP_001059082.1 cold-shock protein -
OCX22_RS04010 (848312) 848312..848530 - 219 WP_000005886.1 hypothetical protein -
OCX22_RS04015 (848592) 848592..848876 - 285 WP_001004401.1 hypothetical protein -
OCX22_RS04020 (848964) 848964..849533 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
OCX22_RS04025 (849721) 849721..849909 - 189 WP_000052076.1 hypothetical protein Toxin
OCX22_RS04030 (849938) 849938..850198 - 261 WP_001059690.1 hypothetical protein Antitoxin
OCX22_RS04035 (850538) 850538..850741 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
OCX22_RS04040 (850738) 850738..850974 - 237 WP_000368687.1 hypothetical protein -
OCX22_RS04045 (851198) 851198..851779 + 582 WP_001140696.1 histidine phosphatase family protein -
OCX22_RS04050 (851852) 851852..852469 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
OCX22_RS04055 (852624) 852624..853118 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
OCX22_RS04060 (853517) 853517..853939 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
OCX22_RS04065 (854087) 854087..854803 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39251 WP_000052076.1 NZ_AP024723:c849909-849721 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39251 NZ_AP024723:c849909-849721 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39251 WP_001059690.1 NZ_AP024723:c850198-849938 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39251 NZ_AP024723:c850198-849938 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References