Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 14763..15234 | Replicon | plasmid IN45P |
| Accession | NZ_AP024719 | ||
| Organism | Methylomarinovum sp. IN45 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | - |
| Locus tag | MIN45_RS12340 | Protein ID | WP_286294200.1 |
| Coordinates | 14763..15032 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | - |
| Locus tag | MIN45_RS12345 | Protein ID | WP_286294201.1 |
| Coordinates | 15016..15234 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIN45_RS12300 (MIN45_PP09) | 10342..11013 | + | 672 | WP_286294192.1 | PEP-CTERM sorting domain-containing protein | - |
| MIN45_RS12305 | 11050..12171 | + | 1122 | WP_286294194.1 | PKD domain-containing protein | - |
| MIN45_RS12310 (MIN45_PP11) | 12503..12712 | + | 210 | WP_286294195.1 | antitoxin MazE family protein | - |
| MIN45_RS12315 (MIN45_PP12) | 12715..13038 | + | 324 | WP_286294224.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MIN45_RS12320 (MIN45_PP13) | 13089..13322 | - | 234 | Protein_13 | type II toxin-antitoxin system HicB family antitoxin | - |
| MIN45_RS12325 (MIN45_PP14) | 13466..14038 | + | 573 | WP_286294197.1 | recombinase family protein | - |
| MIN45_RS12330 (MIN45_PP15) | 14121..14444 | - | 324 | WP_286294199.1 | helix-turn-helix domain-containing protein | - |
| MIN45_RS12335 (MIN45_PP16) | 14434..14715 | - | 282 | WP_286294225.1 | BrnT family toxin | - |
| MIN45_RS12340 (MIN45_PP17) | 14763..15032 | - | 270 | WP_286294200.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MIN45_RS12345 (MIN45_PP18) | 15016..15234 | - | 219 | WP_286294201.1 | DUF6290 family protein | Antitoxin |
| MIN45_RS12350 (MIN45_PP19) | 15608..16096 | + | 489 | WP_286294203.1 | hypothetical protein | - |
| MIN45_RS12355 (MIN45_PP20) | 16204..16608 | + | 405 | WP_286294204.1 | hypothetical protein | - |
| MIN45_RS12360 (MIN45_PP21) | 16733..17155 | + | 423 | WP_286294205.1 | MobC family plasmid mobilization relaxosome protein | - |
| MIN45_RS12365 | 17145..18662 | + | 1518 | WP_286294206.1 | hypothetical protein | - |
| MIN45_RS12370 (MIN45_PP23) | 18685..19119 | + | 435 | WP_286294207.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| MIN45_RS12375 (MIN45_PP24) | 19116..19382 | + | 267 | WP_286294208.1 | toxin-antitoxin system HicB family antitoxin | - |
| MIN45_RS12380 (MIN45_PP25) | 19486..19746 | + | 261 | WP_286294210.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MIN45_RS12385 (MIN45_PP26) | 19743..20129 | + | 387 | WP_286294211.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..20514 | 20514 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10412.97 Da Isoelectric Point: 10.7122
>T39250 WP_286294200.1 NZ_AP024719:c15032-14763 [Methylomarinovum sp. IN45]
MAGRIEYARAARKDVENLDPQVARRIREFLEQRLANLDDPRSIGKPLHGSRLGTFWRYRVGDWRIVASIEEDKVLVLVVR
IGHRREVYG
MAGRIEYARAARKDVENLDPQVARRIREFLEQRLANLDDPRSIGKPLHGSRLGTFWRYRVGDWRIVASIEEDKVLVLVVR
IGHRREVYG
Download Length: 270 bp
>T39250 NZ_AP024719:c15032-14763 [Methylomarinovum sp. IN45]
ATGGCGGGGCGGATTGAATACGCCCGCGCGGCCAGGAAGGACGTCGAGAATCTCGATCCGCAAGTTGCCCGCAGAATCCG
GGAGTTCCTGGAGCAGCGCCTTGCCAACCTGGATGACCCACGCAGCATCGGAAAGCCGTTGCACGGTTCGCGGTTGGGGA
CTTTTTGGCGGTATCGCGTGGGCGACTGGCGGATCGTCGCCAGCATTGAAGAGGACAAGGTTCTCGTGCTCGTGGTGCGG
ATCGGGCACCGACGAGAGGTCTATGGCTAA
ATGGCGGGGCGGATTGAATACGCCCGCGCGGCCAGGAAGGACGTCGAGAATCTCGATCCGCAAGTTGCCCGCAGAATCCG
GGAGTTCCTGGAGCAGCGCCTTGCCAACCTGGATGACCCACGCAGCATCGGAAAGCCGTTGCACGGTTCGCGGTTGGGGA
CTTTTTGGCGGTATCGCGTGGGCGACTGGCGGATCGTCGCCAGCATTGAAGAGGACAAGGTTCTCGTGCTCGTGGTGCGG
ATCGGGCACCGACGAGAGGTCTATGGCTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8250.42 Da Isoelectric Point: 4.5098
>AT39250 WP_286294201.1 NZ_AP024719:c15234-15016 [Methylomarinovum sp. IN45]
MIAVRLPKEIEARLEALAKATKRTKSFYVREALLEYLDDLEDLYLAEQRLIDIRAGKDEVIDGEAFWHGGAD
MIAVRLPKEIEARLEALAKATKRTKSFYVREALLEYLDDLEDLYLAEQRLIDIRAGKDEVIDGEAFWHGGAD
Download Length: 219 bp
>AT39250 NZ_AP024719:c15234-15016 [Methylomarinovum sp. IN45]
ATGATTGCAGTCCGTCTTCCGAAAGAGATCGAGGCACGCCTGGAGGCGTTGGCCAAAGCGACCAAGCGCACAAAGAGCTT
CTACGTCCGCGAAGCGCTGCTGGAGTACTTGGATGATCTGGAGGACCTTTATCTGGCCGAGCAGCGGCTCATCGACATTC
GGGCGGGAAAAGACGAGGTAATCGACGGCGAAGCGTTCTGGCATGGCGGGGCGGATTGA
ATGATTGCAGTCCGTCTTCCGAAAGAGATCGAGGCACGCCTGGAGGCGTTGGCCAAAGCGACCAAGCGCACAAAGAGCTT
CTACGTCCGCGAAGCGCTGCTGGAGTACTTGGATGATCTGGAGGACCTTTATCTGGCCGAGCAGCGGCTCATCGACATTC
GGGCGGGAAAAGACGAGGTAATCGACGGCGAAGCGTTCTGGCATGGCGGGGCGGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|