Detailed information of TA system TA039246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 932837..933507
• Replicon: chromosome
• Accession: NZ_AP024718
• Organism: Methylomarinovum sp. IN45

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MIN45_RS04755
• Protein ID: WP_286293705.1
• Coordinates: 933091..933507 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MIN45_RS04750
• Protein ID: WP_286293704.1
• Coordinates: 932837..933094 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIN45_RS04725 (MIN45_P0908)	929257..929796	-	540	WP_286293699.1	PilX N-terminal domain-containing pilus assembly protein	-
MIN45_RS04730 (MIN45_P0909)	929805..930575	-	771	WP_286293700.1	PilW family protein	-
MIN45_RS04735 (MIN45_P0910)	930572..931114	-	543	WP_286293701.1	type IV pilus modification protein PilV	-
MIN45_RS04740 (MIN45_P0911)	931111..931650	-	540	WP_286293702.1	GspH/FimT family pseudopilin	-
MIN45_RS04745 (MIN45_P0912)	931714..932808	+	1095	WP_286293703.1	hypothetical protein	-
MIN45_RS04750 (MIN45_P0913)	932837..933094	+	258	WP_286293704.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIN45_RS04755 (MIN45_P0914)	933091..933507	+	417	WP_286293705.1	type II toxin-antitoxin system VapC family toxin	Toxin
MIN45_RS04760 (MIN45_P0915)	933485..934168	-	684	WP_286293706.1	alpha/beta hydrolase	-
MIN45_RS04765 (MIN45_P0916)	934165..935145	-	981	WP_286293707.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
MIN45_RS04770 (MIN45_P0917)	935142..936524	-	1383	WP_286293708.1	diguanylate cyclase	-
MIN45_RS04775 (MIN45_P0918)	936578..937171	-	594	WP_286293709.1	hypothetical protein	-
MIN45_RS04780 (MIN45_P0919)	937365..937673	-	309	WP_286293710.1	cell division protein ZapA	-
MIN45_RS04785 (MIN45_P0920)	937670..937891	-	222	WP_286293711.1	TIGR02449 family protein	-
MIN45_RS04790 (MIN45_P0921)	937960..938496	+	537	WP_286293712.1	UPF0149 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-69)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15513.95 Da
• Isoelectric Point: 5.6257

>T39246 WP_286293705.1 NZ_AP024718:933091-933507 [Methylomarinovum sp. IN45]
VSYLLDTNVVCEVVKPNPAPQVIGWLEQVPDVALHLSVLSVGEIRKGVEKLADGPKKERLRLWLEMELPAWFEDRLLSVD
HGVAERWGQLLAGSRRTLPAVDSLLAATALHHELRLVTRNARDFEIPELIVVNPWSTQ

Nucleotide

• Length: 417 bp

>T39246 NZ_AP024718:933091-933507 [Methylomarinovum sp. IN45]
GTGAGTTATCTGCTCGACACCAATGTCGTGTGCGAAGTCGTCAAACCCAATCCAGCGCCCCAGGTGATCGGCTGGCTGGA
ACAGGTGCCCGACGTGGCGCTGCATTTGAGCGTGCTCAGCGTGGGGGAGATTCGCAAAGGCGTGGAAAAGCTGGCGGACG
GCCCGAAAAAGGAGCGACTGCGATTGTGGTTGGAAATGGAGCTGCCCGCATGGTTCGAGGACCGGTTGTTGAGCGTCGAT
CACGGGGTGGCGGAACGTTGGGGACAGCTTTTGGCCGGGTCCAGGCGGACTCTGCCGGCTGTCGACAGCCTGTTGGCGGC
GACGGCGTTGCACCATGAGTTGCGTCTGGTAACGCGCAACGCGCGGGATTTCGAGATTCCGGAATTGATCGTGGTCAATC
CGTGGTCAACCCAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9917.51 Da
• Isoelectric Point: 10.6853

>AT39246 WP_286293704.1 NZ_AP024718:932837-933094 [Methylomarinovum sp. IN45]
MKIRNRWQLQTAKAKLSALVQRARKEGPQEITVRGEGAVVVLSHEDYERLLKRKPSLVEFLRQSPLREVDLTIERDKTPP
RDIDL

Nucleotide

• Length: 258 bp

>AT39246 NZ_AP024718:932837-933094 [Methylomarinovum sp. IN45]
ATGAAAATCCGAAACCGATGGCAGCTGCAAACCGCCAAGGCCAAATTGAGCGCCTTGGTTCAGCGGGCCCGCAAGGAGGG
GCCCCAGGAAATCACCGTCCGCGGCGAAGGGGCGGTCGTGGTGCTTTCCCATGAGGATTACGAGCGGTTGTTGAAGCGCA
AGCCGTCGCTGGTCGAATTCCTGCGCCAGTCGCCACTGCGAGAGGTTGATCTGACAATCGAACGTGACAAAACGCCGCCA
CGGGACATCGATCTGTGA