Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 884293..884873 Replicon chromosome
Accession NZ_AP024718
Organism Methylomarinovum sp. IN45

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MIN45_RS04460 Protein ID WP_286293622.1
Coordinates 884293..884541 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MIN45_RS04465 Protein ID WP_286293624.1
Coordinates 884538..884873 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIN45_RS04415 (MIN45_P0848) 879986..880615 + 630 WP_286293607.1 hypothetical protein -
MIN45_RS04420 (MIN45_P0849) 880679..880879 + 201 WP_286293610.1 helix-turn-helix domain-containing protein -
MIN45_RS04425 (MIN45_P0850) 880890..881201 - 312 WP_286293612.1 BrnA antitoxin family protein -
MIN45_RS04430 (MIN45_P0851) 881215..881478 - 264 WP_286293613.1 BrnT family toxin -
MIN45_RS04435 881533..881739 - 207 Protein_865 ISAs1 family transposase -
MIN45_RS04440 (MIN45_P0852) 882125..882877 - 753 WP_286293615.1 metallophosphoesterase -
MIN45_RS04445 (MIN45_P0853) 883051..883275 + 225 WP_286293617.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MIN45_RS04450 (MIN45_P0854) 883272..883667 + 396 WP_286293619.1 type II toxin-antitoxin system death-on-curing family toxin -
MIN45_RS04455 (MIN45_P0855) 883728..884099 + 372 WP_286293620.1 hypothetical protein -
MIN45_RS04460 (MIN45_P0856) 884293..884541 + 249 WP_286293622.1 type II toxin-antitoxin system HicA family toxin Toxin
MIN45_RS04465 (MIN45_P0857) 884538..884873 + 336 WP_286293624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MIN45_RS04470 (MIN45_P0858) 885243..885596 + 354 WP_286293626.1 hypothetical protein -
MIN45_RS04475 (MIN45_P0859) 885645..886040 - 396 WP_286293627.1 type II toxin-antitoxin system VapC family toxin -
MIN45_RS04480 (MIN45_P0860) 886030..886293 - 264 WP_286293630.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MIN45_RS04490 (MIN45_P0863) 888007..888996 - 990 WP_286293632.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 878610..909333 30723
- flank IS/Tn - - 886507..887364 857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-73)

Antitoxin

Uncharacterised protein family HicB

(55-103)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9591.11 Da        Isoelectric Point: 10.8621

>T39245 WP_286293622.1 NZ_AP024718:884293-884541 [Methylomarinovum sp. IN45]
MAARNKLLNKLHNANKTFPWNDLVTLLNHLDYEKQEMAGSRVRFYNPKTKHMIRLHRPHPENAIKGGALRDIKNTLRAEG
YL

Download         Length: 249 bp

>T39245 NZ_AP024718:884293-884541 [Methylomarinovum sp. IN45]
ATGGCCGCCCGGAACAAGCTGCTGAACAAACTGCACAATGCCAACAAGACGTTTCCCTGGAACGACCTGGTGACGCTGTT
GAACCATTTGGATTACGAGAAGCAGGAAATGGCAGGTTCCCGGGTGCGGTTTTACAACCCCAAGACGAAGCACATGATCC
GCTTGCACCGCCCGCATCCCGAAAACGCCATCAAGGGCGGCGCCTTGCGGGACATCAAAAACACCCTGAGAGCGGAGGGC
TACCTGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12593.48 Da        Isoelectric Point: 6.2388

>AT39245 WP_286293624.1 NZ_AP024718:884538-884873 [Methylomarinovum sp. IN45]
VTTYLTHKGYLGSIEPDLETGRLYGKLLFIRDLVTYEAETLEDLKKEFIASVEAYLEDCKALGKEPDRPCKGTFNVRIPP
ELHRKVVLAAKGKSLNQFVREALEEKLSHAE

Download         Length: 336 bp

>AT39245 NZ_AP024718:884538-884873 [Methylomarinovum sp. IN45]
GTGACGACTTACCTCACCCACAAGGGTTACCTTGGCTCCATCGAGCCGGATCTGGAAACCGGTCGGCTGTACGGCAAGCT
GCTGTTCATCCGTGATCTTGTCACCTACGAGGCGGAAACCCTGGAGGACCTGAAAAAAGAGTTCATCGCTTCGGTCGAAG
CCTATCTGGAGGATTGCAAGGCGCTCGGCAAAGAGCCGGACAGGCCCTGCAAAGGCACCTTCAACGTCCGCATCCCGCCG
GAACTGCACCGGAAGGTTGTCCTGGCAGCCAAAGGCAAAAGCCTCAACCAATTCGTGCGTGAAGCGCTGGAGGAAAAACT
GTCCCATGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References