Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | shpA-brnA/BrnT-BrnA |
| Location | 880890..881478 | Replicon | chromosome |
| Accession | NZ_AP024718 | ||
| Organism | Methylomarinovum sp. IN45 | ||
Toxin (Protein)
| Gene name | shpA | Uniprot ID | - |
| Locus tag | MIN45_RS04430 | Protein ID | WP_286293613.1 |
| Coordinates | 881215..881478 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | MIN45_RS04425 | Protein ID | WP_286293612.1 |
| Coordinates | 880890..881201 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIN45_RS04395 (MIN45_P0844) | 876245..877657 | - | 1413 | WP_286293597.1 | argininosuccinate lyase | - |
| MIN45_RS04400 (MIN45_P0845) | 877736..878560 | + | 825 | WP_286293599.1 | HAD-IIA family hydrolase | - |
| MIN45_RS04405 (MIN45_P0846) | 878610..878813 | + | 204 | WP_286293602.1 | DUF2892 domain-containing protein | - |
| MIN45_RS04410 (MIN45_P0847) | 878901..879881 | + | 981 | WP_286293605.1 | tyrosine-type recombinase/integrase | - |
| MIN45_RS04415 (MIN45_P0848) | 879986..880615 | + | 630 | WP_286293607.1 | hypothetical protein | - |
| MIN45_RS04420 (MIN45_P0849) | 880679..880879 | + | 201 | WP_286293610.1 | helix-turn-helix domain-containing protein | - |
| MIN45_RS04425 (MIN45_P0850) | 880890..881201 | - | 312 | WP_286293612.1 | BrnA antitoxin family protein | Antitoxin |
| MIN45_RS04430 (MIN45_P0851) | 881215..881478 | - | 264 | WP_286293613.1 | BrnT family toxin | Toxin |
| MIN45_RS04435 | 881533..881739 | - | 207 | Protein_865 | ISAs1 family transposase | - |
| MIN45_RS04440 (MIN45_P0852) | 882125..882877 | - | 753 | WP_286293615.1 | metallophosphoesterase | - |
| MIN45_RS04445 (MIN45_P0853) | 883051..883275 | + | 225 | WP_286293617.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MIN45_RS04450 (MIN45_P0854) | 883272..883667 | + | 396 | WP_286293619.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| MIN45_RS04455 (MIN45_P0855) | 883728..884099 | + | 372 | WP_286293620.1 | hypothetical protein | - |
| MIN45_RS04460 (MIN45_P0856) | 884293..884541 | + | 249 | WP_286293622.1 | type II toxin-antitoxin system HicA family toxin | - |
| MIN45_RS04465 (MIN45_P0857) | 884538..884873 | + | 336 | WP_286293624.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MIN45_RS04470 (MIN45_P0858) | 885243..885596 | + | 354 | WP_286293626.1 | hypothetical protein | - |
| MIN45_RS04475 (MIN45_P0859) | 885645..886040 | - | 396 | WP_286293627.1 | type II toxin-antitoxin system VapC family toxin | - |
| MIN45_RS04480 (MIN45_P0860) | 886030..886293 | - | 264 | WP_286293630.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 878610..909333 | 30723 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10363.68 Da Isoelectric Point: 7.2771
>T39244 WP_286293613.1 NZ_AP024718:c881478-881215 [Methylomarinovum sp. IN45]
MMEYEWDDNKAATNLRNHGVTFEAVMDFDWEAATILEDDRRDYGEHRFIAYGPIGDRLHCLVFTLRGRRIRVISLRKANS
REVRRYG
MMEYEWDDNKAATNLRNHGVTFEAVMDFDWEAATILEDDRRDYGEHRFIAYGPIGDRLHCLVFTLRGRRIRVISLRKANS
REVRRYG
Download Length: 264 bp
>T39244 NZ_AP024718:c881478-881215 [Methylomarinovum sp. IN45]
ATGATGGAATACGAATGGGACGACAACAAAGCGGCCACCAACTTGCGCAACCACGGGGTAACCTTCGAGGCGGTGATGGA
CTTCGATTGGGAAGCGGCCACCATCCTTGAAGACGACCGAAGAGACTACGGTGAGCACCGTTTCATCGCCTATGGCCCGA
TCGGCGATCGTCTCCATTGCCTTGTCTTCACCCTGCGTGGGCGCCGAATTCGCGTCATCAGTCTGCGCAAGGCCAACAGC
AGAGAGGTAAGACGCTATGGGTAA
ATGATGGAATACGAATGGGACGACAACAAAGCGGCCACCAACTTGCGCAACCACGGGGTAACCTTCGAGGCGGTGATGGA
CTTCGATTGGGAAGCGGCCACCATCCTTGAAGACGACCGAAGAGACTACGGTGAGCACCGTTTCATCGCCTATGGCCCGA
TCGGCGATCGTCTCCATTGCCTTGTCTTCACCCTGCGTGGGCGCCGAATTCGCGTCATCAGTCTGCGCAAGGCCAACAGC
AGAGAGGTAAGACGCTATGGGTAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11688.09 Da Isoelectric Point: 4.9731
>AT39244 WP_286293612.1 NZ_AP024718:c881201-880890 [Methylomarinovum sp. IN45]
VPTAEDDAEIQRGIEADPDTRELTDEDFGKMRPASEVVPEVVAAYKAGALKRRRGQRGPQKAPTKRLVSIRFSQEVLEYF
RATGPGWQTRMDEALKEWIESQQ
VPTAEDDAEIQRGIEADPDTRELTDEDFGKMRPASEVVPEVVAAYKAGALKRRRGQRGPQKAPTKRLVSIRFSQEVLEYF
RATGPGWQTRMDEALKEWIESQQ
Download Length: 312 bp
>AT39244 NZ_AP024718:c881201-880890 [Methylomarinovum sp. IN45]
GTGCCAACTGCGGAAGATGATGCCGAAATCCAGCGCGGTATCGAGGCAGACCCAGACACGCGGGAACTCACCGATGAGGA
TTTCGGCAAGATGCGCCCTGCCAGCGAGGTGGTGCCGGAAGTCGTGGCCGCATACAAGGCCGGCGCGCTCAAGCGCCGTC
GTGGGCAACGCGGCCCCCAGAAAGCGCCGACGAAACGCCTGGTCTCCATCCGCTTCAGCCAGGAGGTTCTGGAATACTTC
CGCGCCACGGGCCCCGGCTGGCAGACCCGGATGGACGAGGCGCTGAAGGAGTGGATCGAGTCGCAGCAGTGA
GTGCCAACTGCGGAAGATGATGCCGAAATCCAGCGCGGTATCGAGGCAGACCCAGACACGCGGGAACTCACCGATGAGGA
TTTCGGCAAGATGCGCCCTGCCAGCGAGGTGGTGCCGGAAGTCGTGGCCGCATACAAGGCCGGCGCGCTCAAGCGCCGTC
GTGGGCAACGCGGCCCCCAGAAAGCGCCGACGAAACGCCTGGTCTCCATCCGCTTCAGCCAGGAGGTTCTGGAATACTTC
CGCGCCACGGGCCCCGGCTGGCAGACCCGGATGGACGAGGCGCTGAAGGAGTGGATCGAGTCGCAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|