Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT-BrnA
Location 880890..881478 Replicon chromosome
Accession NZ_AP024718
Organism Methylomarinovum sp. IN45

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag MIN45_RS04430 Protein ID WP_286293613.1
Coordinates 881215..881478 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag MIN45_RS04425 Protein ID WP_286293612.1
Coordinates 880890..881201 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIN45_RS04395 (MIN45_P0844) 876245..877657 - 1413 WP_286293597.1 argininosuccinate lyase -
MIN45_RS04400 (MIN45_P0845) 877736..878560 + 825 WP_286293599.1 HAD-IIA family hydrolase -
MIN45_RS04405 (MIN45_P0846) 878610..878813 + 204 WP_286293602.1 DUF2892 domain-containing protein -
MIN45_RS04410 (MIN45_P0847) 878901..879881 + 981 WP_286293605.1 tyrosine-type recombinase/integrase -
MIN45_RS04415 (MIN45_P0848) 879986..880615 + 630 WP_286293607.1 hypothetical protein -
MIN45_RS04420 (MIN45_P0849) 880679..880879 + 201 WP_286293610.1 helix-turn-helix domain-containing protein -
MIN45_RS04425 (MIN45_P0850) 880890..881201 - 312 WP_286293612.1 BrnA antitoxin family protein Antitoxin
MIN45_RS04430 (MIN45_P0851) 881215..881478 - 264 WP_286293613.1 BrnT family toxin Toxin
MIN45_RS04435 881533..881739 - 207 Protein_865 ISAs1 family transposase -
MIN45_RS04440 (MIN45_P0852) 882125..882877 - 753 WP_286293615.1 metallophosphoesterase -
MIN45_RS04445 (MIN45_P0853) 883051..883275 + 225 WP_286293617.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MIN45_RS04450 (MIN45_P0854) 883272..883667 + 396 WP_286293619.1 type II toxin-antitoxin system death-on-curing family toxin -
MIN45_RS04455 (MIN45_P0855) 883728..884099 + 372 WP_286293620.1 hypothetical protein -
MIN45_RS04460 (MIN45_P0856) 884293..884541 + 249 WP_286293622.1 type II toxin-antitoxin system HicA family toxin -
MIN45_RS04465 (MIN45_P0857) 884538..884873 + 336 WP_286293624.1 type II toxin-antitoxin system HicB family antitoxin -
MIN45_RS04470 (MIN45_P0858) 885243..885596 + 354 WP_286293626.1 hypothetical protein -
MIN45_RS04475 (MIN45_P0859) 885645..886040 - 396 WP_286293627.1 type II toxin-antitoxin system VapC family toxin -
MIN45_RS04480 (MIN45_P0860) 886030..886293 - 264 WP_286293630.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 878610..909333 30723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(19-99)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10363.68 Da        Isoelectric Point: 7.2771

>T39244 WP_286293613.1 NZ_AP024718:c881478-881215 [Methylomarinovum sp. IN45]
MMEYEWDDNKAATNLRNHGVTFEAVMDFDWEAATILEDDRRDYGEHRFIAYGPIGDRLHCLVFTLRGRRIRVISLRKANS
REVRRYG

Download         Length: 264 bp

>T39244 NZ_AP024718:c881478-881215 [Methylomarinovum sp. IN45]
ATGATGGAATACGAATGGGACGACAACAAAGCGGCCACCAACTTGCGCAACCACGGGGTAACCTTCGAGGCGGTGATGGA
CTTCGATTGGGAAGCGGCCACCATCCTTGAAGACGACCGAAGAGACTACGGTGAGCACCGTTTCATCGCCTATGGCCCGA
TCGGCGATCGTCTCCATTGCCTTGTCTTCACCCTGCGTGGGCGCCGAATTCGCGTCATCAGTCTGCGCAAGGCCAACAGC
AGAGAGGTAAGACGCTATGGGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11688.09 Da        Isoelectric Point: 4.9731

>AT39244 WP_286293612.1 NZ_AP024718:c881201-880890 [Methylomarinovum sp. IN45]
VPTAEDDAEIQRGIEADPDTRELTDEDFGKMRPASEVVPEVVAAYKAGALKRRRGQRGPQKAPTKRLVSIRFSQEVLEYF
RATGPGWQTRMDEALKEWIESQQ

Download         Length: 312 bp

>AT39244 NZ_AP024718:c881201-880890 [Methylomarinovum sp. IN45]
GTGCCAACTGCGGAAGATGATGCCGAAATCCAGCGCGGTATCGAGGCAGACCCAGACACGCGGGAACTCACCGATGAGGA
TTTCGGCAAGATGCGCCCTGCCAGCGAGGTGGTGCCGGAAGTCGTGGCCGCATACAAGGCCGGCGCGCTCAAGCGCCGTC
GTGGGCAACGCGGCCCCCAGAAAGCGCCGACGAAACGCCTGGTCTCCATCCGCTTCAGCCAGGAGGTTCTGGAATACTTC
CGCGCCACGGGCCCCGGCTGGCAGACCCGGATGGACGAGGCGCTGAAGGAGTGGATCGAGTCGCAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References