Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 590250..590904 Replicon chromosome
Accession NZ_AP024718
Organism Methylomarinovum sp. IN45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIN45_RS02935 Protein ID WP_286293273.1
Coordinates 590509..590904 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIN45_RS02930 Protein ID WP_286293271.1
Coordinates 590250..590501 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIN45_RS02910 (MIN45_P0557) 585539..586756 - 1218 WP_286293266.1 FAD-dependent monooxygenase -
MIN45_RS02915 (MIN45_P0558) 586913..587188 - 276 WP_286293267.1 RNA-binding protein -
MIN45_RS02920 (MIN45_P0559) 587511..587996 - 486 WP_286293268.1 DnaJ domain-containing protein -
MIN45_RS02925 (MIN45_P0560) 588039..590201 + 2163 WP_286293270.1 ABC transporter substrate-binding protein -
MIN45_RS02930 (MIN45_P0561) 590250..590501 + 252 WP_286293271.1 antitoxin Antitoxin
MIN45_RS02935 (MIN45_P0562) 590509..590904 + 396 WP_286293273.1 PIN domain-containing protein Toxin
MIN45_RS02940 (MIN45_P0563) 590901..591878 + 978 WP_286293275.1 ABC transporter permease -
MIN45_RS02945 (MIN45_P0564) 591875..593206 + 1332 WP_286293276.1 ABC transporter permease -
MIN45_RS02950 (MIN45_P0565) 593371..594201 + 831 WP_286293277.1 phosphoserine phosphatase SerB -
MIN45_RS02955 (MIN45_P0566) 594198..595817 + 1620 WP_286293279.1 dipeptide ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14737.97 Da        Isoelectric Point: 8.5523

>T39243 WP_286293273.1 NZ_AP024718:590509-590904 [Methylomarinovum sp. IN45]
MDTDTCIFLIRHHPPEARERFQAIGPTHLFISTVTLFELAYGAERSRRQAHNRACLQRLVALLNLVPFDTEAAWTAARLR
AELAAAGTPIGPYDVQIAAIALSRNMTLVSNNLREFRRIADLRSETWVLPA

Download         Length: 396 bp

>T39243 NZ_AP024718:590509-590904 [Methylomarinovum sp. IN45]
TTGGATACGGACACCTGCATCTTTCTGATCCGCCACCATCCGCCGGAAGCGCGGGAACGTTTCCAGGCCATCGGGCCGAC
GCATCTGTTCATCTCTACCGTCACGCTGTTCGAACTGGCTTACGGCGCCGAACGCAGCCGCAGGCAGGCGCACAACCGCG
CCTGCCTGCAGCGCCTGGTGGCGCTGTTGAATCTCGTTCCCTTCGATACCGAAGCCGCCTGGACGGCAGCCCGTCTCCGG
GCCGAACTGGCCGCAGCCGGCACCCCCATCGGCCCTTACGACGTTCAGATCGCCGCCATCGCCCTCAGCCGCAACATGAC
GCTGGTATCCAACAATCTGCGGGAATTCCGCCGTATCGCCGACCTGCGCAGCGAAACCTGGGTATTGCCGGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9705.88 Da        Isoelectric Point: 4.6787

>AT39243 WP_286293271.1 NZ_AP024718:590250-590501 [Methylomarinovum sp. IN45]
MKTTKVFRSGNSQAIRLPKEFRLDCDTVTIHREGRRLIIEPVEDWAGRLYAVLEDFSDDFMAEGRDHPQPQVRPELESLF
DDN

Download         Length: 252 bp

>AT39243 NZ_AP024718:590250-590501 [Methylomarinovum sp. IN45]
ATGAAAACCACGAAAGTTTTTCGGAGCGGCAATTCCCAAGCCATTCGCCTGCCCAAAGAGTTTCGTCTCGACTGCGACAC
CGTCACCATCCACCGCGAGGGACGCCGTCTGATCATCGAGCCTGTGGAAGACTGGGCCGGGCGGTTGTATGCGGTCCTGG
AAGATTTTTCCGACGATTTCATGGCGGAAGGCCGTGATCACCCCCAACCCCAGGTGCGCCCGGAACTGGAAAGCCTGTTC
GACGATAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References