Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3740202..3740731 | Replicon | chromosome |
| Accession | NZ_AP024671 | ||
| Organism | Mycobacterium tuberculosis strain R2092 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | K5645_RS17450 | Protein ID | WP_003417760.1 |
| Coordinates | 3740474..3740731 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | K5645_RS17445 | Protein ID | WP_003417757.1 |
| Coordinates | 3740202..3740477 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5645_RS20765 (MTR2092_34750) | 3736775..3737464 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| K5645_RS20770 (MTR2092_34760) | 3737651..3738022 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| K5645_RS20775 | 3737920..3738138 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| K5645_RS20780 (MTR2092_34770) | 3738165..3738425 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| K5645_RS17430 (MTR2092_34780) | 3738540..3738929 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| K5645_RS17435 (MTR2092_34790) | 3738943..3739236 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| K5645_RS17440 (MTR2092_34800) | 3739233..3740078 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| K5645_RS17445 (MTR2092_34810) | 3740202..3740477 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| K5645_RS17450 (MTR2092_34820) | 3740474..3740731 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| K5645_RS17455 (MTR2092_34830) | 3740773..3741963 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| K5645_RS17460 (MTR2092_34840) | 3742080..3742448 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| K5645_RS17465 (MTR2092_34850) | 3742445..3742996 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| K5645_RS17470 (MTR2092_34860) | 3743003..3743584 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| K5645_RS17475 (MTR2092_34870) | 3743565..3743933 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| K5645_RS17480 (MTR2092_34880) | 3743911..3744303 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T39201 WP_003417760.1 NZ_AP024671:3740474-3740731 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T39201 NZ_AP024671:3740474-3740731 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT39201 WP_003417757.1 NZ_AP024671:3740202-3740477 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT39201 NZ_AP024671:3740202-3740477 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|