Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3671563..3672237 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag K5645_RS17255 Protein ID WP_003417282.1
Coordinates 3671563..3671991 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag K5645_RS17260 Protein ID WP_003417286.1
Coordinates 3671995..3672237 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS17230 (MTR2092_34290) 3667385..3667786 - 402 WP_003417264.1 cytidine deaminase -
K5645_RS17235 (MTR2092_34300) 3668023..3668361 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
K5645_RS17240 (MTR2092_34310) 3668358..3668792 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
K5645_RS17245 (MTR2092_34320) 3668921..3670693 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
K5645_RS17250 (MTR2092_34330) 3670693..3671484 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
K5645_RS17255 (MTR2092_34340) 3671563..3671991 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
K5645_RS17260 (MTR2092_34350) 3671995..3672237 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
K5645_RS17265 (MTR2092_34360) 3672359..3672973 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
K5645_RS17270 (MTR2092_34370) 3672970..3673635 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
K5645_RS17275 (MTR2092_34380) 3673636..3674169 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
K5645_RS17280 (MTR2092_34390) 3674166..3674540 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
K5645_RS17285 (MTR2092_34400) 3674637..3675773 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T39200 WP_003417282.1 NZ_AP024671:c3671991-3671563 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T39200 NZ_AP024671:c3671991-3671563 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT39200 WP_003417286.1 NZ_AP024671:c3672237-3671995 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT39200 NZ_AP024671:c3672237-3671995 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References