Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3139388..3139936 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag K5645_RS14840 Protein ID WP_003414602.1
Coordinates 3139673..3139936 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag K5645_RS14835 Protein ID WP_003414599.1
Coordinates 3139388..3139669 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS14810 (MTR2092_29440) 3135011..3135868 - 858 WP_003899513.1 type I methionyl aminopeptidase -
K5645_RS14815 (MTR2092_29450) 3135910..3136494 - 585 WP_003414585.1 DUF1707 domain-containing protein -
K5645_RS14820 3136598..3136846 + 249 WP_003913411.1 antitoxin VapB23 -
K5645_RS14825 (MTR2092_29460) 3136843..3137223 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
K5645_RS14830 (MTR2092_29470) 3137305..3139116 - 1812 WP_003414596.1 penicillin-binding protein -
K5645_RS14835 (MTR2092_29490) 3139388..3139669 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
K5645_RS14840 (MTR2092_29500) 3139673..3139936 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5645_RS14845 (MTR2092_29510) 3140309..3141163 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
K5645_RS14850 (MTR2092_29520) 3141219..3142382 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
K5645_RS14855 (MTR2092_29530) 3142399..3143613 - 1215 WP_003414610.1 zinc metalloprotease Rip -
K5645_RS14860 (MTR2092_29540) 3143621..3144862 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T39197 WP_003414602.1 NZ_AP024671:3139673-3139936 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T39197 NZ_AP024671:3139673-3139936 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT39197 WP_003414599.1 NZ_AP024671:3139388-3139669 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT39197 NZ_AP024671:3139388-3139669 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References