Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3098471..3099075 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag K5645_RS14640 Protein ID WP_003414492.1
Coordinates 3098471..3098863 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag K5645_RS14645 Protein ID WP_003414495.1
Coordinates 3098860..3099075 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS14610 (MTR2092_29040) 3093621..3094409 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
K5645_RS14615 (MTR2092_29050) 3094743..3095288 - 546 WP_014584866.1 DUF1802 family protein -
K5645_RS14620 (MTR2092_29060) 3095560..3096444 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
K5645_RS14625 (MTR2092_29070) 3096447..3097334 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
K5645_RS14630 (MTR2092_29080) 3097639..3098184 - 546 WP_003899500.1 DUF1802 family protein -
K5645_RS14635 (MTR2092_29090) 3098181..3098450 - 270 WP_003414489.1 DUF2277 family protein -
K5645_RS14640 (MTR2092_29100) 3098471..3098863 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
K5645_RS14645 (MTR2092_29110) 3098860..3099075 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5645_RS14650 (MTR2092_29120) 3099122..3099871 + 750 WP_003902358.1 enoyl-CoA hydratase -
K5645_RS14655 (MTR2092_29130) 3099950..3101032 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
K5645_RS14660 (MTR2092_29140) 3101025..3102335 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
K5645_RS14665 (MTR2092_29150) 3102338..3103165 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
K5645_RS14670 (MTR2092_29160) 3103162..3104073 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T39196 WP_003414492.1 NZ_AP024671:c3098863-3098471 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T39196 NZ_AP024671:c3098863-3098471 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT39196 WP_003414495.1 NZ_AP024671:c3099075-3098860 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT39196 NZ_AP024671:c3099075-3098860 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References