Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2897933..2898647 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag K5645_RS13470 Protein ID WP_003413460.1
Coordinates 2898207..2898647 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag K5645_RS13465 Protein ID WP_003413456.1
Coordinates 2897933..2898220 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS13430 (MTR2092_26770) 2893355..2893600 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
K5645_RS13435 (MTR2092_26780) 2893597..2894001 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
K5645_RS13440 (MTR2092_26790) 2894218..2894838 + 621 WP_003413441.1 DUF4178 domain-containing protein -
K5645_RS13445 2894849..2895343 + 495 WP_003413444.1 DUF2617 family protein -
K5645_RS13450 (MTR2092_26820) 2895340..2895771 + 432 WP_003899390.1 DUF4247 domain-containing protein -
K5645_RS13455 (MTR2092_26830) 2895796..2896254 + 459 WP_003413451.1 DUF350 domain-containing protein -
K5645_RS13460 (MTR2092_26840) 2896251..2897822 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
K5645_RS13465 (MTR2092_26850) 2897933..2898220 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
K5645_RS13470 (MTR2092_26860) 2898207..2898647 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
K5645_RS13475 (MTR2092_26870) 2898668..2899423 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
K5645_RS13480 (MTR2092_26880) 2899556..2900152 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
K5645_RS13485 (MTR2092_26890) 2900160..2901005 - 846 WP_003413466.1 acyl-CoA thioesterase II -
K5645_RS13490 (MTR2092_26900) 2901034..2901933 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
K5645_RS13495 (MTR2092_26910) 2902061..2902735 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T39190 WP_003413460.1 NZ_AP024671:2898207-2898647 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T39190 NZ_AP024671:2898207-2898647 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT39190 WP_003413456.1 NZ_AP024671:2897933-2898220 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT39190 NZ_AP024671:2897933-2898220 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References