Detailed information of TA system TA039184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2381938..2382467
• Replicon: chromosome
• Accession: NZ_AP024671
• Organism: Mycobacterium tuberculosis strain R2092

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: K5645_RS11050
• Protein ID: WP_003411124.1
• Coordinates: 2381938..2382255 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: K5645_RS11055
• Protein ID: WP_003411127.1
• Coordinates: 2382252..2382467 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5645_RS11020 (MTR2092_22160)	2377075..2378151	+	1077	WP_003411110.1	hypothetical protein	-
K5645_RS11025 (MTR2092_22170)	2378148..2378429	+	282	WP_003411112.1	DUF5703 family protein	-
K5645_RS11030 (MTR2092_22180)	2378465..2379538	+	1074	WP_003901338.1	quinone-dependent dihydroorotate dehydrogenase	-
K5645_RS11035 (MTR2092_22190)	2379543..2380073	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
K5645_RS11040 (MTR2092_22200)	2380121..2381467	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
K5645_RS11050 (MTR2092_22210)	2381938..2382255	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5645_RS11055 (MTR2092_22220)	2382252..2382467	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
K5645_RS11060	2382722..2383780	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
K5645_RS11065 (MTR2092_22250)	2383910..2384266	-	357	WP_003411130.1	hypothetical protein	-
K5645_RS11070 (MTR2092_22260)	2384361..2385143	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
K5645_RS11075 (MTR2092_22270)	2385411..2385701	-	291	WP_221062928.1	YggT family protein	-
K5645_RS11080 (MTR2092_22280)	2385863..2386519	-	657	WP_003411133.1	cell division protein SepF	-
K5645_RS11085 (MTR2092_22290)	2386585..2387361	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T39184 WP_003411124.1 NZ_AP024671:c2382255-2381938 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T39184 NZ_AP024671:c2382255-2381938 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT39184 WP_003411127.1 NZ_AP024671:c2382467-2382252 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT39184 NZ_AP024671:c2382467-2382252 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4