Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2208923..2209509 | Replicon | chromosome |
| Accession | NZ_AP024671 | ||
| Organism | Mycobacterium tuberculosis strain R2092 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | K5645_RS10250 | Protein ID | WP_003410010.1 |
| Coordinates | 2208923..2209267 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | K5645_RS10255 | Protein ID | WP_003410014.1 |
| Coordinates | 2209261..2209509 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5645_RS10215 (MTR2092_20400) | 2204629..2205228 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| K5645_RS10220 | 2205644..2206072 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| K5645_RS10225 (MTR2092_20420) | 2206298..2206837 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| K5645_RS10230 (MTR2092_20430) | 2207357..2207917 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| K5645_RS10235 (MTR2092_20440) | 2207914..2208255 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| K5645_RS10240 (MTR2092_20450) | 2208341..2208598 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| K5645_RS10245 (MTR2092_20460) | 2208499..2208834 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| K5645_RS10250 (MTR2092_20470) | 2208923..2209267 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| K5645_RS10255 (MTR2092_20480) | 2209261..2209509 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| K5645_RS10260 (MTR2092_20490) | 2209609..2211924 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| K5645_RS10265 (MTR2092_20500) | 2211921..2212193 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| K5645_RS10270 (MTR2092_20510) | 2212246..2212602 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| K5645_RS10275 (MTR2092_20520) | 2212759..2213526 | + | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T39179 WP_003410010.1 NZ_AP024671:c2209267-2208923 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T39179 NZ_AP024671:c2209267-2208923 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT39179 WP_003410014.1 NZ_AP024671:c2209509-2209261 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT39179 NZ_AP024671:c2209509-2209261 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|