Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2207357..2208255 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag K5645_RS10230 Protein ID WP_003410001.1
Coordinates 2207357..2207917 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag K5645_RS10235 Protein ID WP_003410003.1
Coordinates 2207914..2208255 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS10200 (MTR2092_20370) 2202526..2203179 - 654 WP_003409976.1 cutinase Cfp21 -
K5645_RS10205 (MTR2092_20380) 2203294..2203524 + 231 WP_003409980.1 DUF167 domain-containing protein -
K5645_RS10210 (MTR2092_20390) 2203609..2204520 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
K5645_RS10215 (MTR2092_20400) 2204629..2205228 + 600 WP_003409989.1 L-lysine exporter -
K5645_RS10220 2205644..2206072 + 429 WP_003409992.1 cellulose-binding protein -
K5645_RS10225 (MTR2092_20420) 2206298..2206837 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
K5645_RS10230 (MTR2092_20430) 2207357..2207917 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
K5645_RS10235 (MTR2092_20440) 2207914..2208255 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
K5645_RS10240 (MTR2092_20450) 2208341..2208598 + 258 WP_003410006.1 hypothetical protein -
K5645_RS10245 (MTR2092_20460) 2208499..2208834 - 336 WP_003410009.1 dehydrogenase -
K5645_RS10250 (MTR2092_20470) 2208923..2209267 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
K5645_RS10255 (MTR2092_20480) 2209261..2209509 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
K5645_RS10260 (MTR2092_20490) 2209609..2211924 - 2316 WP_003899120.1 cation transporter ATPase CptG -
K5645_RS10265 (MTR2092_20500) 2211921..2212193 - 273 WP_003410017.1 DUF1490 family protein -
K5645_RS10270 (MTR2092_20510) 2212246..2212602 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T39178 WP_003410001.1 NZ_AP024671:c2207917-2207357 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T39178 NZ_AP024671:c2207917-2207357 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT39178 WP_003410003.1 NZ_AP024671:c2208255-2207914 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT39178 NZ_AP024671:c2208255-2207914 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References