Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2178986..2179530 | Replicon | chromosome |
| Accession | NZ_AP024671 | ||
| Organism | Mycobacterium tuberculosis strain R2092 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | K5645_RS10045 | Protein ID | WP_003409896.1 |
| Coordinates | 2178986..2179282 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | K5645_RS10050 | Protein ID | WP_003409899.1 |
| Coordinates | 2179279..2179530 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5645_RS09990 (MTR2092_19940) | 2174019..2174369 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| K5645_RS09995 | 2174380..2175282 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| K5645_RS10000 (MTR2092_19970) | 2175303..2175494 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| K5645_RS10005 (MTR2092_19980) | 2175495..2175791 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| K5645_RS10010 (MTR2092_19990) | 2176031..2176246 | + | 216 | WP_003409878.1 | antitoxin | - |
| K5645_RS10015 (MTR2092_20000) | 2176243..2176554 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| K5645_RS10020 | 2176528..2177049 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| K5645_RS10025 (MTR2092_20020) | 2177024..2177401 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| K5645_RS10030 (MTR2092_20030) | 2177443..2177892 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| K5645_RS10035 (MTR2092_20040) | 2177889..2178434 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| K5645_RS10040 | 2178323..2178937 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| K5645_RS10045 (MTR2092_20060) | 2178986..2179282 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K5645_RS10050 (MTR2092_20070) | 2179279..2179530 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K5645_RS10055 (MTR2092_20080) | 2179517..2180011 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| K5645_RS10060 (MTR2092_20090) | 2180171..2180578 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| K5645_RS10065 (MTR2092_20100) | 2180582..2180854 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| K5645_RS10070 (MTR2092_20110) | 2180887..2182107 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| K5645_RS10075 (MTR2092_20130) | 2183006..2183803 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T39176 WP_003409896.1 NZ_AP024671:c2179282-2178986 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T39176 NZ_AP024671:c2179282-2178986 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT39176 WP_003409899.1 NZ_AP024671:c2179530-2179279 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT39176 NZ_AP024671:c2179530-2179279 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |