Detailed information of TA system TA039169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1385081..1385640
• Replicon: chromosome
• Accession: NZ_AP024671
• Organism: Mycobacterium tuberculosis strain R2092

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: K5645_RS06500
• Protein ID: WP_003898789.1
• Coordinates: 1385081..1385374 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: K5645_RS06505
• Protein ID: WP_003406322.1
• Coordinates: 1385371..1385640 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5645_RS06475 (MTR2092_12870)	1380779..1381039	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
K5645_RS06480 (MTR2092_12880)	1381036..1381467	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
K5645_RS06485 (MTR2092_12890)	1381490..1383073	-	1584	WP_009940130.1	PE family protein	-
K5645_RS06490 (MTR2092_12910)	1383253..1384113	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
K5645_RS06495 (MTR2092_12920)	1384194..1385024	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
K5645_RS06500 (MTR2092_12930)	1385081..1385374	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
K5645_RS06505 (MTR2092_12940)	1385371..1385640	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K5645_RS06510 (MTR2092_12950)	1385753..1389448	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
K5645_RS06515 (MTR2092_12960)	1389590..1390378	-	789	WP_221063018.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T39169 WP_003898789.1 NZ_AP024671:c1385374-1385081 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T39169 NZ_AP024671:c1385374-1385081 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT39169 WP_003406322.1 NZ_AP024671:c1385640-1385371 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT39169 NZ_AP024671:c1385640-1385371 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2