Detailed information of TA system TA039168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1380779..1381467
• Replicon: chromosome
• Accession: NZ_AP024671
• Organism: Mycobacterium tuberculosis strain R2092

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: K5645_RS06480
• Protein ID: WP_003406304.1
• Coordinates: 1381036..1381467 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: K5645_RS06475
• Protein ID: WP_003406302.1
• Coordinates: 1380779..1381039 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5645_RS06455 (MTR2092_12830)	1376356..1377180	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
K5645_RS06460 (MTR2092_12840)	1377185..1378366	+	1182	WP_221063017.1	trehalose ABC transporter ATP-binding protein SugC	-
K5645_RS06465 (MTR2092_12850)	1378443..1379543	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
K5645_RS06470 (MTR2092_12860)	1379714..1380703	+	990	WP_003406301.1	malate dehydrogenase	-
K5645_RS06475 (MTR2092_12870)	1380779..1381039	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
K5645_RS06480 (MTR2092_12880)	1381036..1381467	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
K5645_RS06485 (MTR2092_12890)	1381490..1383073	-	1584	WP_009940130.1	PE family protein	-
K5645_RS06490 (MTR2092_12910)	1383253..1384113	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
K5645_RS06495 (MTR2092_12920)	1384194..1385024	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
K5645_RS06500 (MTR2092_12930)	1385081..1385374	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
K5645_RS06505 (MTR2092_12940)	1385371..1385640	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T39168 WP_003406304.1 NZ_AP024671:1381036-1381467 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T39168 NZ_AP024671:1381036-1381467 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT39168 WP_003406302.1 NZ_AP024671:1380779-1381039 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT39168 NZ_AP024671:1380779-1381039 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6