Detailed information of TA system TA039167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1235917..1236485
• Replicon: chromosome
• Accession: NZ_AP024671
• Organism: Mycobacterium tuberculosis strain R2092

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: K5645_RS05835
• Protein ID: WP_003405865.1
• Coordinates: 1236111..1236485 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: K5645_RS05830
• Protein ID: WP_003405863.1
• Coordinates: 1235917..1236114 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5645_RS05810 (MTR2092_11480)	1231958..1232596	-	639	WP_003898730.1	lipid droplet-associated protein	-
K5645_RS05815 (MTR2092_11490)	1232686..1233693	+	1008	WP_003405853.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
K5645_RS05820 (MTR2092_11500)	1233710..1234693	-	984	WP_003898731.1	hypothetical protein	-
K5645_RS05825 (MTR2092_11510)	1234756..1235829	+	1074	WP_003898732.1	redox-regulated ATPase YchF	-
K5645_RS05830 (MTR2092_11520)	1235917..1236114	+	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
K5645_RS05835 (MTR2092_11530)	1236111..1236485	+	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
K5645_RS05840 (MTR2092_11540)	1236688..1237386	+	699	WP_003898733.1	hypothetical protein	-
K5645_RS05845 (MTR2092_11550)	1237504..1237689	+	186	WP_003901093.1	hypothetical protein	-
K5645_RS05850 (MTR2092_11560)	1237616..1237891	-	276	WP_003405867.1	hypothetical protein	-
K5645_RS05855 (MTR2092_11570)	1238134..1238457	+	324	WP_003405871.1	putative quinol monooxygenase	-
K5645_RS05860 (MTR2092_11580)	1238472..1239170	-	699	WP_031646953.1	hypothetical protein	-
K5645_RS05865	1239204..1239413	+	210	WP_003911400.1	hypothetical protein	-
K5645_RS05870 (MTR2092_11600)	1239365..1240135	-	771	Protein_1173	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T39167 WP_003405865.1 NZ_AP024671:1236111-1236485 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T39167 NZ_AP024671:1236111-1236485 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT39167 WP_003405863.1 NZ_AP024671:1235917-1236114 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT39167 NZ_AP024671:1235917-1236114 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07