Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 707882..708507 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag K5645_RS03205 Protein ID WP_003403218.1
Coordinates 708106..708507 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag K5645_RS03200 Protein ID WP_003403213.1
Coordinates 707882..708109 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS03175 (MTR2092_06290) 703061..703282 - 222 WP_003898525.1 DUF4926 domain-containing protein -
K5645_RS03180 (MTR2092_06300) 703424..704029 + 606 WP_003898526.1 hypothetical protein -
K5645_RS03185 (MTR2092_06310) 704048..706615 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
K5645_RS03190 (MTR2092_06320) 706699..707448 + 750 WP_003898528.1 hypothetical protein -
K5645_RS03195 (MTR2092_06330) 707445..707687 + 243 WP_003403210.1 hypothetical protein -
K5645_RS03200 (MTR2092_06340) 707882..708109 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
K5645_RS03205 (MTR2092_06350) 708106..708507 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
K5645_RS20420 708636..708719 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
K5645_RS20425 708738..709819 + 1082 Protein_642 galactose-1-phosphate uridylyltransferase -
K5645_RS03220 (MTR2092_06380) 709816..710907 + 1092 WP_003900977.1 galactokinase -
K5645_RS03225 (MTR2092_06400) 711302..712366 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
K5645_RS03230 (MTR2092_06410) 712470..713417 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T39156 WP_003403218.1 NZ_AP024671:708106-708507 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T39156 NZ_AP024671:708106-708507 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT39156 WP_003403213.1 NZ_AP024671:707882-708109 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT39156 NZ_AP024671:707882-708109 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References