Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 700344..700987 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag K5645_RS03155 Protein ID WP_003403187.1
Coordinates 700586..700987 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag K5645_RS03150 Protein ID WP_003403184.1
Coordinates 700344..700589 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS03115 (MTR2092_06180) 695624..696154 - 531 WP_003917320.1 two component system sensor kinase HK2 -
K5645_RS03120 (MTR2092_06190) 696138..696833 - 696 WP_003918099.1 two-component system response regulator TcrA -
K5645_RS03125 (MTR2092_06200) 696956..697267 + 312 WP_003403164.1 hypothetical protein -
K5645_RS03130 (MTR2092_06210) 697339..698289 + 951 WP_003900184.1 DUF1259 domain-containing protein -
K5645_RS03135 (MTR2092_06220) 698530..699114 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
K5645_RS03140 (MTR2092_06230) 699116..699826 + 711 Protein_627 IS607 family element RNA-guided endonuclease TnpB -
K5645_RS03145 (MTR2092_06240) 699829..700299 + 471 WP_003898523.1 hypothetical protein -
K5645_RS03150 (MTR2092_06250) 700344..700589 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5645_RS03155 (MTR2092_06260) 700586..700987 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
K5645_RS20415 700978..701157 + 180 Protein_631 hypothetical protein -
K5645_RS03165 (MTR2092_06270) 701575..701772 - 198 WP_003403191.1 hypothetical protein -
K5645_RS03170 (MTR2092_06280) 701852..703009 - 1158 WP_003898524.1 hypothetical protein -
K5645_RS03175 (MTR2092_06290) 703061..703282 - 222 WP_003898525.1 DUF4926 domain-containing protein -
K5645_RS03180 (MTR2092_06300) 703424..704029 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T39155 WP_003403187.1 NZ_AP024671:700586-700987 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T39155 NZ_AP024671:700586-700987 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT39155 WP_003403184.1 NZ_AP024671:700344-700589 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT39155 NZ_AP024671:700344-700589 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References