Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 637319..637995 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag K5645_RS02850 Protein ID WP_003898500.1
Coordinates 637319..637732 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag K5645_RS02855 Protein ID WP_003402915.1
Coordinates 637729..637995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS02820 (MTR2092_05590) 632664..632966 - 303 WP_003402896.1 DUF3349 domain-containing protein -
K5645_RS02825 (MTR2092_05600) 633026..633304 - 279 WP_003402901.1 hypothetical protein -
K5645_RS02830 (MTR2092_05610) 633301..634554 - 1254 WP_003402904.1 inorganic phosphate transporter -
K5645_RS02835 (MTR2092_05620) 634674..635060 - 387 WP_003402907.1 VOC family protein -
K5645_RS02840 (MTR2092_05630) 635123..636007 - 885 WP_003402909.1 SDR family oxidoreductase -
K5645_RS02845 (MTR2092_05640) 636103..637005 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
K5645_RS02850 (MTR2092_05650) 637319..637732 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
K5645_RS02855 (MTR2092_05660) 637729..637995 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
K5645_RS02860 (MTR2092_05670) 638187..639902 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
K5645_RS02865 (MTR2092_05680) 639980..641584 + 1605 WP_003402920.1 amidohydrolase -
K5645_RS02870 (MTR2092_05690) 641581..642561 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T39151 WP_003898500.1 NZ_AP024671:c637732-637319 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T39151 NZ_AP024671:c637732-637319 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT39151 WP_003402915.1 NZ_AP024671:c637995-637729 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT39151 NZ_AP024671:c637995-637729 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References