Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 360529..361100 Replicon chromosome
Accession NZ_AP024671
Organism Mycobacterium tuberculosis strain R2092

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag K5645_RS01565 Protein ID WP_003401560.1
Coordinates 360529..360831 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag K5645_RS01570 Protein ID WP_003401563.1
Coordinates 360879..361100 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5645_RS01545 (MTR2092_03070) 355989..356792 - 804 WP_003401540.1 Stf0 family sulphotransferase -
K5645_RS01550 (MTR2092_03080) 356802..358199 - 1398 WP_003401544.1 sulfatase -
K5645_RS01555 (MTR2092_03090) 358378..360162 + 1785 WP_031740504.1 PE family protein -
K5645_RS01560 (MTR2092_03100) 360305..360532 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
K5645_RS01565 (MTR2092_03110) 360529..360831 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
K5645_RS01570 (MTR2092_03120) 360879..361100 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K5645_RS01575 (MTR2092_03130) 361097..361522 + 426 WP_003401566.1 PIN domain nuclease -
K5645_RS01580 (MTR2092_03140) 361658..362290 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
K5645_RS01585 (MTR2092_03150) 362287..363195 + 909 WP_003900117.1 protochlorophyllide reductase -
K5645_RS20395 363203..363793 - 591 WP_229298012.1 hypothetical protein -
K5645_RS20400 363786..363836 - 51 Protein_316 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T39148 WP_003401560.1 NZ_AP024671:360529-360831 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T39148 NZ_AP024671:360529-360831 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT39148 WP_003401563.1 NZ_AP024671:360879-361100 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT39148 NZ_AP024671:360879-361100 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References