Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3191078..3191526 Replicon chromosome
Accession NZ_AP024620
Organism Moorella sp. Hama-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NGH78_RS15560 Protein ID WP_161955095.1
Coordinates 3191078..3191311 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NGH78_RS15565 Protein ID WP_109207592.1
Coordinates 3191308..3191526 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGH78_RS15545 (hamaS1_31280) 3187009..3188622 - 1614 WP_109207595.1 CTP synthase -
NGH78_RS15550 (hamaS1_31290) 3188737..3190419 - 1683 WP_109207594.1 arginine--tRNA ligase -
NGH78_RS15555 (hamaS1_31300) 3190474..3190908 - 435 WP_109207593.1 DUF1934 domain-containing protein -
NGH78_RS15560 (hamaS1_31320) 3191078..3191311 - 234 WP_161955095.1 type II toxin-antitoxin system HicA family toxin Toxin
NGH78_RS15565 (hamaS1_31330) 3191308..3191526 - 219 WP_109207592.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGH78_RS15570 (hamaS1_31340) 3191611..3191814 - 204 WP_277998668.1 hypothetical protein -
NGH78_RS15575 (hamaS1_31350) 3191879..3193573 - 1695 WP_109208281.1 IS1634 family transposase -
NGH78_RS15580 (hamaS1_31360) 3193659..3194621 - 963 WP_251955047.1 3-deoxy-7-phosphoheptulonate synthase -
NGH78_RS15585 (hamaS1_31380) 3195089..3195535 - 447 WP_109207589.1 PIN domain-containing protein -
NGH78_RS15590 (hamaS1_31390) 3195513..3195734 - 222 WP_109207588.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(13-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-67)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8887.42 Da        Isoelectric Point: 10.8035

>T38960 WP_161955095.1 NZ_AP024620:c3191311-3191078 [Moorella sp. Hama-1]
MSRVPVVNFKLMDKVLQNLGFQPVRQKGSHIFYRHPDGRTTTVPNHPGRSLAIPLVREILREIELAPGEFLEEIRKL

Download         Length: 234 bp

>T38960 NZ_AP024620:c3191311-3191078 [Moorella sp. Hama-1]
ATGAGCCGGGTCCCGGTTGTTAATTTCAAGTTAATGGATAAAGTGTTACAAAATCTAGGTTTTCAGCCTGTCAGGCAGAA
AGGTAGCCATATATTTTACCGGCATCCTGATGGCAGGACTACGACGGTACCCAATCATCCGGGACGTAGCCTTGCCATCC
CCCTTGTACGCGAAATCCTGCGGGAGATCGAACTGGCGCCGGGTGAATTTCTCGAAGAGATTAGGAAATTGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8125.30 Da        Isoelectric Point: 4.3915

>AT38960 WP_109207592.1 NZ_AP024620:c3191526-3191308 [Moorella sp. Hama-1]
MKTFTAYVEWDPETKLYVGSVPGVSGAHTQGETLDELQRNLKEVLELCLEEYKGKLENLPKFVGLQQIEVAI

Download         Length: 219 bp

>AT38960 NZ_AP024620:c3191526-3191308 [Moorella sp. Hama-1]
ATGAAAACTTTTACGGCCTACGTGGAGTGGGACCCGGAGACGAAATTGTATGTTGGTAGTGTGCCAGGGGTGTCGGGCGC
TCACACCCAGGGAGAAACCCTGGATGAGTTACAGAGAAATTTAAAGGAAGTTTTGGAGCTTTGTCTTGAGGAATACAAGG
GGAAGCTTGAAAATTTACCTAAATTTGTTGGTCTGCAACAGATCGAGGTCGCCATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References