Detailed information of TA system TA038959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2836645..2837272
• Replicon: chromosome
• Accession: NZ_AP024620
• Organism: Moorella sp. Hama-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: NGH78_RS13905
• Protein ID: WP_277997085.1
• Coordinates: 2836645..2836992 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: NGH78_RS13910
• Protein ID: WP_109205587.1
• Coordinates: 2836997..2837272 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGH78_RS13870 (hamaS1_27840)	2832354..2832848	-	495	WP_109205592.1	ribosomal protein S18-alanine N-acetyltransferase	-
NGH78_RS13875 (hamaS1_27850)	2832845..2833531	-	687	WP_109205591.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
NGH78_RS13880 (hamaS1_27860)	2833512..2833979	-	468	WP_109205590.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
NGH78_RS13885 (hamaS1_27870)	2834054..2834629	-	576	WP_109205791.1	uracil-DNA glycosylase	-
NGH78_RS13890 (hamaS1_27880)	2834683..2835330	-	648	WP_109205790.1	thiamine phosphate synthase	-
NGH78_RS13895 (hamaS1_27890)	2835392..2835772	-	381	WP_235612772.1	response regulator	-
NGH78_RS13900 (hamaS1_27900)	2835929..2836630	-	702	WP_109205789.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
NGH78_RS13905 (hamaS1_27910)	2836645..2836992	-	348	WP_277997085.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
NGH78_RS13910 (hamaS1_27920)	2836997..2837272	-	276	WP_109205587.1	ribbon-helix-helix protein, CopG family	Antitoxin
NGH78_RS13915 (hamaS1_27930)	2837383..2838504	-	1122	WP_109205586.1	alanine racemase	-
NGH78_RS13920 (hamaS1_27940)	2838526..2840076	-	1551	WP_109205585.1	NAD(P)H-hydrate dehydratase	-
NGH78_RS13925 (hamaS1_27950)	2840227..2840661	-	435	WP_109205584.1	holo-ACP synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12599.56 Da
• Isoelectric Point: 7.2036

>T38959 WP_277997085.1 NZ_AP024620:c2836992-2836645 [Moorella sp. Hama-1]
MVRRGDVFYAHLNPVVGSEQGGTRPVLIIQNDIGNQYSPTTIVAAITSQIAKAKLPTHVEIAASKSGLERDSVILLEQIR
TIDKSRLKQKVAVLDDEILERVNRALEISLGLVEV

Nucleotide

• Length: 348 bp

>T38959 NZ_AP024620:c2836992-2836645 [Moorella sp. Hama-1]
CTGGTACGGCGCGGGGATGTCTTTTATGCCCATCTCAACCCGGTGGTTGGTTCCGAGCAAGGCGGAACCCGCCCGGTACT
TATCATTCAAAATGACATTGGCAACCAGTATAGCCCTACCACCATTGTGGCTGCCATTACCTCCCAGATTGCCAAGGCCA
AGTTGCCCACCCACGTAGAAATTGCGGCCAGCAAAAGCGGCCTGGAGCGGGATTCTGTTATCCTGCTGGAACAGATCCGT
ACCATCGACAAAAGCCGCCTCAAACAAAAGGTGGCCGTCCTGGATGATGAAATCCTGGAGAGGGTCAACCGGGCCCTGGA
GATCAGCCTGGGCCTGGTAGAAGTGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10766.49 Da
• Isoelectric Point: 8.8541

>AT38959 WP_109205587.1 NZ_AP024620:c2837272-2836997 [Moorella sp. Hama-1]
MPGVKRIMISLPESLLAEVDGLATLEKRNRSEFIREAMKLYITERKRRNIREQMKRGYQEMAPINLALAVENYDIENEVQ
RYYDKSLAECK

Nucleotide

• Length: 276 bp

>AT38959 NZ_AP024620:c2837272-2836997 [Moorella sp. Hama-1]
TTGCCAGGTGTCAAGCGGATCATGATCAGCTTGCCGGAGAGCCTCCTGGCCGAGGTTGACGGCCTGGCGACCTTGGAAAA
GCGCAATCGCAGCGAATTTATCCGGGAAGCTATGAAGTTATATATCACCGAACGTAAACGGCGTAATATCCGTGAACAGA
TGAAACGGGGATACCAGGAAATGGCACCTATCAATTTAGCCCTTGCAGTGGAAAACTATGATATAGAGAATGAAGTGCAA
CGGTACTACGATAAAAGCCTGGCGGAGTGTAAATAA