Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1177719..1178305 Replicon chromosome
Accession NZ_AP024620
Organism Moorella sp. Hama-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NGH78_RS05910 Protein ID WP_109207128.1
Coordinates 1177958..1178305 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NGH78_RS05905 Protein ID WP_109207127.1
Coordinates 1177719..1177964 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGH78_RS05885 (hamaS1_11580) 1173230..1173559 + 330 WP_109207124.1 STAS domain-containing protein -
NGH78_RS05890 (hamaS1_11590) 1173559..1175412 + 1854 WP_161955038.1 FapA family protein -
NGH78_RS05895 (hamaS1_11600) 1175518..1175940 + 423 WP_109207125.1 c-type cytochrome -
NGH78_RS05900 (hamaS1_11610) 1175937..1177403 + 1467 WP_109207126.1 cbb3-type cytochrome c oxidase subunit I -
NGH78_RS05905 (hamaS1_11620) 1177719..1177964 + 246 WP_109207127.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NGH78_RS05910 (hamaS1_11630) 1177958..1178305 + 348 WP_109207128.1 endoribonuclease MazF Toxin
NGH78_RS05915 (hamaS1_11640) 1178361..1179518 + 1158 WP_109207129.1 ASKHA domain-containing protein -
NGH78_RS05920 (hamaS1_11650) 1179745..1180347 + 603 WP_109207242.1 hypothetical protein -
NGH78_RS05925 (hamaS1_11660) 1180277..1181158 + 882 WP_251955068.1 hypothetical protein -
NGH78_RS05935 (hamaS1_11680) 1181745..1182635 + 891 WP_256468605.1 nitrite reductase -
NGH78_RS05940 (hamaS1_11690) 1182671..1183063 + 393 WP_109206208.1 DsrE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1172522..1185599 13077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-113)

Antitoxin

SpoVT-AbrB domain

(10-48)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12648.87 Da        Isoelectric Point: 9.0982

>T38958 WP_109207128.1 NZ_AP024620:1177958-1178305 [Moorella sp. Hama-1]
MVNEMETYIPERGDIVWLQFDPRAGHEQAGRRLALVVSPQLYNGKVGLALFCPVTTKAKGYPFEVKIPAGLKITGVILAD
QLKSLDWRAREAQFACKVPVGVVAEVQAKVQVLIS

Download         Length: 348 bp

>T38958 NZ_AP024620:1177958-1178305 [Moorella sp. Hama-1]
ATGGTAAACGAGATGGAAACCTATATTCCCGAACGTGGTGATATCGTCTGGCTCCAGTTCGATCCCCGGGCAGGACATGA
GCAAGCCGGCAGGCGACTGGCGCTGGTAGTTTCCCCGCAACTTTATAACGGCAAAGTAGGGCTAGCCCTTTTTTGCCCTG
TTACTACAAAGGCGAAGGGTTATCCCTTTGAAGTAAAGATACCCGCTGGTTTAAAGATTACTGGAGTAATCCTGGCCGAC
CAGCTAAAAAGCCTTGACTGGCGGGCAAGGGAGGCGCAATTTGCTTGTAAGGTCCCGGTCGGGGTAGTAGCAGAAGTCCA
GGCTAAAGTTCAGGTATTGATTTCCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9050.44 Da        Isoelectric Point: 7.3187

>AT38958 WP_109207127.1 NZ_AP024620:1177719-1177964 [Moorella sp. Hama-1]
VKIFMQPHVQKWGNSLGIRIPLALAQKTGLREGTPVDLLVDEDAIIIRRKHYSLEQLLAQVTPGNTHGEIDTGPQVGREV
W

Download         Length: 246 bp

>AT38958 NZ_AP024620:1177719-1177964 [Moorella sp. Hama-1]
GTGAAAATCTTTATGCAACCTCATGTGCAAAAATGGGGCAATAGTTTAGGGATTCGTATCCCTTTAGCGCTGGCCCAAAA
AACCGGCCTGAGGGAAGGCACACCGGTTGACTTGCTGGTAGATGAGGACGCAATAATTATCCGTCGTAAACATTATAGCC
TGGAACAATTGCTGGCACAGGTTACACCCGGTAATACTCATGGTGAAATAGATACTGGGCCTCAGGTGGGGCGGGAAGTA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References