Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2516477..2518026 Replicon chromosome
Accession NZ_AP024617
Organism Shewanella algae strain TUM17386

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5631_RS11150 Protein ID WP_208170572.1
Coordinates 2516725..2518026 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5631_RS11145 Protein ID WP_025011264.1
Coordinates 2516477..2516725 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5631_RS11130 (TUM17386_21910) 2511952..2513877 + 1926 WP_208170574.1 U32 family peptidase -
K5631_RS11135 (TUM17386_21920) 2513888..2514262 + 375 WP_014386412.1 PH domain-containing protein -
K5631_RS11140 (TUM17386_21930) 2514273..2515964 - 1692 WP_208170573.1 ATP-binding cassette domain-containing protein -
K5631_RS11145 (TUM17386_21940) 2516477..2516725 + 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5631_RS11150 (TUM17386_21950) 2516725..2518026 + 1302 WP_208170572.1 type II toxin-antitoxin system HipA family toxin Toxin
K5631_RS11155 (TUM17386_21960) 2518167..2519534 - 1368 WP_025011265.1 L-cystine transporter -
K5631_RS11160 (TUM17386_21970) 2519838..2521865 + 2028 WP_144168445.1 S9 family peptidase -
K5631_RS11165 (TUM17386_21980) 2521943..2522527 - 585 WP_044733696.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48672.48 Da        Isoelectric Point: 9.6241

>T38954 WP_208170572.1 NZ_AP024617:2516725-2518026 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPLEHPYKKEPLSYEILNNKKLEAVLSAYKSDIPLGMLKEEENFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIEQIMKLLMGSSNALEDRYNFMRFQIFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPENISNSIFENAKKTIKKI

Download         Length: 1302 bp

>T38954 NZ_AP024617:2516725-2518026 [Shewanella algae]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGCACCTTGGCGAAGCATAAGAACGGCGCTCACACTTTTCA
ATATGATAAGGACTGGATAACCAATGCAATGGCTCGCCCACTGTCATTGTCTTTGAGGCTTCAATTACCGACTATCACTT
CCGATGCCGTTATCAACTATTTTGACAACCTCTTACCAGACAGCCCACAAGTCAGAGATAGGATCGTTGCAAGGTACAAA
GCCTCGTCCAAACAACCATTTGATCTCTTGAAAGAAATTGGAAAGGATAGTGTTGGTGCTATTGCACTATTTCCTCTCGA
ACACCCCTATAAAAAAGAGCCACTCAGCTACGAAATATTGAATAACAAGAAACTAGAAGCCGTTCTTTCTGCATACAAGT
CTGATATTCCCCTCGGGATGCTCAAAGAGGAAGAAAACTTTAGGATCTCAGTGGCAGGTGCTCAAGAAAAAACCGCACTC
TTATTCATTGATGGACAATGGTGTATACCGAAAGGAAACACCCCAACCACTCACATTATCAAGCTGCCAATAGGCGAAAT
ACCACAAGCTAACGCGACACTGGATCTCAAAGATAGCGTAGAAAATGAATATCTTTGCATTGAGCTAGCTAAAGCGCTGG
GATTCGCAGTTCCCAGCGTCAATATAATCAAAACAGACAACCTTAAAGCTTTAGCTGTAGAACGATTTGATCGACGCTGG
ACAAAAGACAGAGCAGGCTTGCTACGCTTACCTCAAGAAGATATTTGCCAAGTGTTTGGTATGCCATCATCCATCAAATA
TGAATCTCAAGGTGGTCCAGGCATAGAACAGATCATGAAGTTATTAATGGGCTCAAGTAATGCACTTGAAGATCGATATA
ACTTCATGAGATTCCAGATATTTCAATGGATCATTGGGGCTACGGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AGAGGAGGTAGCTATCGACTCACTCCATTCTACGACATTCTTTCAGCCTACCCATTACTGGGAGGAAAAGGACTCAATAT
TAGACAACTTAAGCTCGCAATGGGGTTAAAAGCCACAAAAGGCAAGAAGTATGAAATCAATAAAATCCTGCCTCGTCACT
TTTTAGATACTGCTAAAGCTGTGAATTTTAGTCAGGATAAGATGCAAAGAATAATGGATGAAATGAAAGGTGCGTTACCT
GAGGCAATCTCGCAAGTAAGGGCGAATCTACCCGAGGGCTTTCCAGAGAATATCTCCAACTCTATTTTTGAGAATGCCAA
GAAAACAATTAAAAAAATCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT38954 WP_025011264.1 NZ_AP024617:2516477-2516725 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT38954 NZ_AP024617:2516477-2516725 [Shewanella algae]
ATGATATATAGTCCAAAGCAACTCGCAGATATGATGCTACTGATACGCCAAAAGAATGGCTGGACTCAGTCAGAGTTGGC
GAAAAAAGTCGGTATAAAGCAAGCAACAATCTCGAACTTCGAGAACAACCCCAACAAAACAACGCTTTCTACCTTCTTTA
AGCTTGTACAAGCTATGGATCTAACACTGAGTATCCAAGAAAAAACACAGCTGACTTCGCCAAGTGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References