Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4116495..4118035 Replicon chromosome
Accession NZ_AP024616
Organism Shewanella algae strain TUM17384

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5627_RS18330 Protein ID WP_221059115.1
Coordinates 4116495..4117796 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5627_RS18335 Protein ID WP_093982108.1
Coordinates 4117799..4118035 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5627_RS18300 (TUM17384_36040) 4111686..4111961 + 276 WP_221059112.1 hypothetical protein -
K5627_RS18305 (TUM17384_36050) 4112013..4112447 + 435 WP_020442396.1 HNH endonuclease -
K5627_RS18310 (TUM17384_36060) 4112786..4113133 + 348 WP_025011793.1 hypothetical protein -
K5627_RS18315 (TUM17384_36070) 4113536..4114699 + 1164 WP_221059113.1 RNA ligase RtcB family protein -
K5627_RS18320 (TUM17384_36080) 4114699..4115334 + 636 WP_208159071.1 peptide chain release factor H -
K5627_RS18325 (TUM17384_36090) 4115481..4116434 - 954 WP_221059114.1 tetratricopeptide repeat protein -
K5627_RS18330 (TUM17384_36100) 4116495..4117796 - 1302 WP_221059115.1 HipA domain-containing protein Toxin
K5627_RS18335 (TUM17384_36110) 4117799..4118035 - 237 WP_093982108.1 helix-turn-helix domain-containing protein Antitoxin
K5627_RS18340 (TUM17384_36120) 4118243..4118929 - 687 WP_221059116.1 cold shock domain-containing protein -
K5627_RS18345 4118899..4119264 + 366 WP_208124744.1 hypothetical protein -
K5627_RS18350 (TUM17384_36140) 4120062..4120808 + 747 WP_221059117.1 hypothetical protein -
K5627_RS18355 (TUM17384_36170) 4121225..4121749 + 525 WP_221059118.1 ATP-binding protein -
K5627_RS21755 (TUM17384_36180) 4121959..4122342 + 384 WP_259663439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48498.26 Da        Isoelectric Point: 4.7370

>T38952 WP_221059115.1 NZ_AP024616:c4117796-4116495 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEDPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGRHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLNGLD
NDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T38952 NZ_AP024616:c4117796-4116495 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGATCCCGCCAC
CGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCAGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGCTTGGATTACCTCATCGAATCT
CTCGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATTGGCTTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTACGCCTGGAAGATCCTGAGC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTATTCTACAAC
GGCAAGCAATTTGGTTTCGGTGAAGGCGCCTTATCATCGACCCATATCCTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGTCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCGGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAGCAGCGGGTGCTGAGAAGGCATATTATCGAT
AGTTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
TGAAGGCGTGAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCAGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCCTGTATGAGGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCGTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACCAGAATAAGCCAAGAAATAGATGGTGTTATCGCAATGCTCAATGGATTGGAT
AACGATGAGCAAGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGCGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8487.03 Da        Isoelectric Point: 9.6887

>AT38952 WP_093982108.1 NZ_AP024616:c4118035-4117799 [Shewanella algae]
MASPLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT38952 NZ_AP024616:c4118035-4117799 [Shewanella algae]
ATGGCCTCCCCATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCGGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGCCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References