Detailed information of TA system TA038951

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3498214..3498856
• Replicon: chromosome
• Accession: NZ_AP024616
• Organism: Shewanella algae strain TUM17384

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: -
• Locus tag: K5627_RS15560
• Protein ID: WP_208193390.1
• Coordinates: 3498214..3498636 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5627_RS15565
• Protein ID: WP_028779782.1
• Coordinates: 3498617..3498856 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5627_RS15535 (TUM17384_30560)	3493731..3494210	-	480	WP_025010554.1	SoxR reducing system RseC family protein	-
K5627_RS15540 (TUM17384_30570)	3494221..3495153	-	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
K5627_RS15545 (TUM17384_30580)	3495163..3495783	-	621	WP_025887842.1	RseA family anti-sigma factor	-
K5627_RS15550 (TUM17384_30590)	3495808..3496386	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5627_RS15555 (TUM17384_30600)	3496586..3498196	+	1611	WP_025010550.1	L-aspartate oxidase	-
K5627_RS15560 (TUM17384_30610)	3498214..3498636	-	423	WP_208193390.1	protein YgfX	Toxin
K5627_RS15565 (TUM17384_30620)	3498617..3498856	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5627_RS15570 (TUM17384_30630)	3498955..3499863	-	909	WP_025010548.1	transcriptional activator NhaR	-
K5627_RS15575 (TUM17384_30640)	3499880..3500263	-	384	WP_037474378.1	hypothetical protein	-
K5627_RS15580 (TUM17384_30650)	3500260..3501435	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5627_RS15585 (TUM17384_30660)	3501552..3502346	-	795	WP_071238278.1	thymidylate synthase	-
K5627_RS15590 (TUM17384_30670)	3502346..3503173	-	828	WP_071238279.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16295.79 Da
• Isoelectric Point: 6.4249

>T38951 WP_208193390.1 NZ_AP024616:c3498636-3498214 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSNSAN

Nucleotide

• Length: 423 bp

>T38951 NZ_AP024616:c3498636-3498214 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAATTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38951 WP_028779782.1 NZ_AP024616:c3498856-3498617 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38951 NZ_AP024616:c3498856-3498617 [Shewanella algae]
ATGAGTACCCCCAGAGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTATTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1