Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 802196..803745 Replicon chromosome
Accession NZ_AP024616
Organism Shewanella algae strain TUM17384

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5627_RS03685 Protein ID WP_159352467.1
Coordinates 802196..803497 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5627_RS03690 Protein ID WP_025011264.1
Coordinates 803497..803745 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5627_RS03670 (TUM17384_07080) 797695..798279 + 585 WP_117200305.1 LysE family translocator -
K5627_RS03675 (TUM17384_07090) 798357..800384 - 2028 WP_221059401.1 S9 family peptidase -
K5627_RS03680 (TUM17384_07100) 800688..802055 + 1368 WP_028781110.1 L-cystine transporter -
K5627_RS03685 (TUM17384_07110) 802196..803497 - 1302 WP_159352467.1 type II toxin-antitoxin system HipA family toxin Toxin
K5627_RS03690 (TUM17384_07120) 803497..803745 - 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5627_RS03695 (TUM17384_07130) 804257..805948 + 1692 WP_144224924.1 ATP-binding cassette domain-containing protein -
K5627_RS03700 (TUM17384_07140) 805961..806335 - 375 WP_014386412.1 PH domain-containing protein -
K5627_RS03705 (TUM17384_07150) 806346..808271 - 1926 WP_107005534.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48616.51 Da        Isoelectric Point: 9.6959

>T38949 WP_159352467.1 NZ_AP024616:c803497-802196 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPPITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMKLLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
KAISQVRANLPEGFPEHISNSIFENAKKIIKKI

Download         Length: 1302 bp

>T38949 NZ_AP024616:c803497-802196 [Shewanella algae]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGCACCTTGGCGAAGCATAAGAACGGCGCCCACACTTTTCA
ATATGATAAGGACTGGATAACCAATGCAATGGCTCGCCCACTGTCATTGTCTTTGAGGCTTCAATTACCACCTATTACTT
CCGATGCCGTTATCAACTATTTTGACAACCTCTTACCAGACAGCCCACAAGTCAGAGATAGGATCGTTGCAAGGTACAAA
GCCTCGTCCAAACAACCATTTGATCTTTTGAAAGAAATTGGAAAGGATAGTGTTGGTGCTATTGCACTATTTCCTCCCGA
ACACCCCTATAAAAAAGAGCCGCTCAGCTACGAAATATTGGATAACAAGAAACTAGAAGCCGTTCTTTCTGCATACAAGT
CTGATATTCCCCTCGGAATGCTCAAAGAGGAAGAAGACTTTAGGATCTCAGTGGCAGGTGCTCAAGAAAAAACCGCACTC
TTATTCATTGATGGACAATGGTGTATACCGAAAGGAAACACCCCAACCACTCACATTATCAAGCTGCCAATAGGCGAAAT
ACCACAAGCTAACGCGACCCTGGATCTCAAAGATAGCGTAGAAAATGAATATCTTTGCATTGAGCTAGCTAAAGCGCTGG
GATTCGCAGTTCCCAGCGTCAATATAATCAAAACTGACAACCTTAAAGCTTTAGCTGTAGAACGATTTGATCGACGTTGG
ACAAAAGACAGAGCAGGCTTGCTACGCTTACCTCAAGAAGATATTTGCCAGGTGTTTGGTATGCCATCATCCATCAAATA
TGAATCTCAAGGTGGCCCAGGCATAGCACAGATCATGAAGTTATTAATGGGCTCAAGTAATGCACTTGAAGATCGATATA
ACTTCATGAGATTCCAGGTATTTCAATGGATCATTGGGGCTACGGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AGAGGAGGTAGCTATCGACTCACTCCATTCTACGACATTCTGTCGGCCTACCCATTACTGGGAGGAAAAGGACTCAATAT
TAGACAACTTAAGCTCGCAATGGGATTAAAAGCCACAAAAGGCAAGAAGTACGAAATCAATAAAATCCTGCCTCGTCACT
TTTTAGATACTGCTAAAGCTGTGAATTTTAGTCAGGATAAGATGCAAAGAATAATGGATGAAATGAAAGGTGCGTTACCT
AAGGCAATCTCGCAAGTAAGGGCGAATCTACCAGAGGGCTTTCCAGAGCATATCTCCAACTCAATTTTTGAGAATGCCAA
GAAAATAATTAAAAAAATCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT38949 WP_025011264.1 NZ_AP024616:c803745-803497 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT38949 NZ_AP024616:c803745-803497 [Shewanella algae]
ATGATATATAGTCCAAAGCAACTCGCAGATATGATGCTACTGATACGCCAAAAGAATGGCTGGACTCAGTCAGAGTTGGC
GAAAAAAGTCGGTATAAAGCAAGCAACAATCTCGAACTTCGAGAACAACCCCAACAAAACAACGCTTTCTACCTTCTTTA
AGCTTGTACAAGCTATGGATCTAACACTGAGTATCCAAGAAAAAACACAGCTGACTTCGCCAAGTGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References