Detailed information of TA system TA038948

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3533153..3533795
• Replicon: chromosome
• Accession: NZ_AP024615
• Organism: Shewanella algae strain TUM17383

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0A5N5U1D5
• Locus tag: K5632_RS15615
• Protein ID: WP_025010549.1
• Coordinates: 3533153..3533575 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5632_RS15620
• Protein ID: WP_028779782.1
• Coordinates: 3533556..3533795 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5632_RS15590 (TUM17383_30750)	3528670..3529149	-	480	WP_025887846.1	SoxR reducing system RseC family protein	-
K5632_RS15595 (TUM17383_30760)	3529160..3530092	-	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
K5632_RS15600 (TUM17383_30770)	3530102..3530722	-	621	WP_190532857.1	RseA family anti-sigma factor	-
K5632_RS15605 (TUM17383_30780)	3530747..3531325	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5632_RS15610 (TUM17383_30790)	3531525..3533135	+	1611	WP_025010550.1	L-aspartate oxidase	-
K5632_RS15615 (TUM17383_30800)	3533153..3533575	-	423	WP_025010549.1	protein YgfX	Toxin
K5632_RS15620 (TUM17383_30810)	3533556..3533795	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5632_RS15625 (TUM17383_30820)	3533894..3534802	-	909	WP_025010548.1	transcriptional activator NhaR	-
K5632_RS15630 (TUM17383_30830)	3534819..3535202	-	384	WP_062793820.1	hypothetical protein	-
K5632_RS15635 (TUM17383_30840)	3535199..3536374	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5632_RS15640 (TUM17383_30850)	3536491..3537285	-	795	WP_208124982.1	thymidylate synthase	-
K5632_RS15645 (TUM17383_30860)	3537285..3538112	-	828	WP_093982518.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16309.86 Da
• Isoelectric Point: 7.0359

>T38948 WP_025010549.1 NZ_AP024615:c3533575-3533153 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38948 NZ_AP024615:c3533575-3533153 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCGGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38948 WP_028779782.1 NZ_AP024615:c3533795-3533556 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38948 NZ_AP024615:c3533795-3533556 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1