Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 795502..797051 Replicon chromosome
Accession NZ_AP024615
Organism Shewanella algae strain TUM17383

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5632_RS03650 Protein ID WP_221055790.1
Coordinates 795502..796803 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5632_RS03655 Protein ID WP_025011264.1
Coordinates 796803..797051 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5632_RS03635 (TUM17383_07090) 791001..791585 + 585 WP_221055789.1 LysE family translocator -
K5632_RS03640 (TUM17383_07100) 791663..793690 - 2028 WP_208146312.1 S9 family peptidase -
K5632_RS03645 (TUM17383_07110) 793994..795361 + 1368 WP_093982365.1 L-cystine transporter -
K5632_RS03650 (TUM17383_07120) 795502..796803 - 1302 WP_221055790.1 type II toxin-antitoxin system HipA family toxin Toxin
K5632_RS03655 (TUM17383_07130) 796803..797051 - 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5632_RS03660 (TUM17383_07140) 797564..799255 + 1692 WP_221055791.1 ATP-binding cassette domain-containing protein -
K5632_RS03665 (TUM17383_07150) 799268..799642 - 375 WP_014386412.1 PH domain-containing protein -
K5632_RS03670 (TUM17383_07160) 799653..801578 - 1926 WP_208134011.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48787.41 Da        Isoelectric Point: 8.8140

>T38946 WP_221055790.1 NZ_AP024615:c796803-795502 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEFLCIELARALEFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMELLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLSPFYDILSAYPLMGRKGLNIQQLKLGMGLEATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPEHISNSIFENAKKTIKKI

Download         Length: 1302 bp

>T38946 NZ_AP024615:c796803-795502 [Shewanella algae]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGCACCTTGGCGAAGCATAAGAACGGCGCTCACACTTTTCA
ATATGATAAGGACTGGATAACCAATGCAATGGCTCGCCCACTGTCATTGTCTTTGAGGCTTCAATTACCGACTATCACTT
CCGATGCCGTTATCAACTATTTTGACAACCTCTTACCAGACAGCCCACAAGTCAGAGATAGGATCGTTGCAAGGTACAAA
GCCTCGTCCAAACAACCATTTGATCTCTTGAAAGAAATTGGAAAGGATAGTGTTGGTGCTATTGCACTATTTCCTCCCGA
ACACCCCTATAAAAAAGAGCCACTCAGCTACGAAATATTGGATAACAAGAAACTAGAAGCCGTTCTTTCTGCATACAAGT
CTGATATCCCCCTCGGGATGCTCAAAGAGGAAGAAGACTTTAGGATCTCAGTGGCAGGTGCTCAAGAAAAAACCGCACTC
TTATTCATTGATGGACAATGGTGTATACCGAAAGGAAACACCCCAACCACTCACATTATCAAGCTGCCAATAGGCGAAAT
ACAACAAGCTAACGCGACACTGGATCTCAAAGATAGCGTAGAAAATGAGTTTCTTTGCATTGAGCTAGCGAGAGCTCTGG
AATTCGCAGTTCCCAGCGTCAATATAATCAAAACAGACAACCTTAAAGCTTTAGCTGTAGAACGATTTGATCGACGCTGG
ACAAAAGACAGAGCTGGCTTACTACGCTTACCTCAAGAAGATATTTGCCAAGTGTTTGGTATGCCATCATCCATCAAATA
TGAATCTCAAGGTGGCCCAGGCATAGCACAGATCATGGAGTTATTAATGGGTTCAAGTAATGCACTTGAAGATCGATATA
ACTTCATGAGATTCCAGGTATTTCAATGGATCATTGGGGCTACGGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AGAGGAGGTAGCTATCGACTCAGTCCATTCTACGACATTCTGTCAGCCTACCCATTAATGGGAAGAAAAGGACTAAATAT
TCAACAACTTAAGCTCGGCATGGGGTTGGAGGCCACAAAAGGCAAGAAGTATGAAATCAATAAAATCCTGCCTCGTCACT
TTTTAGATACTGCTAAAGCTGTGAATTTTAGTCAGGATAAGATGCAAAGAATAATGGATGAAATGAAAGGTGCGTTACCT
GAGGCAATCTCGCAAGTAAGGGCGAATCTACCGGAGGGCTTTCCAGAGCATATCTCCAACTCAATTTTTGAGAATGCCAA
GAAAACAATTAAAAAAATCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT38946 WP_025011264.1 NZ_AP024615:c797051-796803 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT38946 NZ_AP024615:c797051-796803 [Shewanella algae]
ATGATATATAGTCCAAAGCAACTCGCAGATATGATGCTACTGATACGCCAAAAGAATGGCTGGACTCAGTCAGAGTTGGC
GAAAAAAGTCGGTATAAAGCAAGCAACAATCTCGAACTTCGAGAACAACCCCAACAAAACAACGCTTTCTACCTTCTTTA
AGCTTGTACAAGCTATGGATCTAACACTGAGTATCCAAGAAAAAACACAGCTGACTTCGCCAAGTGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References