Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4349273..4351062 Replicon chromosome
Accession NZ_AP024613
Organism Shewanella algae strain TUM17379

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5628_RS19440 Protein ID WP_208139384.1
Coordinates 4349725..4351062 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5628_RS19435 Protein ID WP_208147841.1
Coordinates 4349273..4349728 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5628_RS19420 (TUM17379_38340) 4346697..4346972 - 276 WP_208147838.1 hypothetical protein -
K5628_RS19425 (TUM17379_38350) 4347180..4347698 - 519 WP_123117050.1 ankyrin repeat domain-containing protein -
K5628_RS19430 (TUM17379_38360) 4347704..4348912 - 1209 WP_208147839.1 GH-E family nuclease -
K5628_RS19435 (TUM17379_38370) 4349273..4349728 - 456 WP_208147841.1 helix-turn-helix domain-containing protein Antitoxin
K5628_RS19440 (TUM17379_38380) 4349725..4351062 - 1338 WP_208139384.1 HipA domain-containing protein Toxin
K5628_RS19445 (TUM17379_38390) 4351223..4352434 - 1212 WP_107005245.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(163-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(86-141)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 50739.46 Da        Isoelectric Point: 4.7687

>T38943 WP_208139384.1 NZ_AP024613:c4351062-4349725 [Shewanella algae]
MEHLTIQAFINSQWIDIAKLSFPNSEQGHYRLTSLDYEQDYALAELNKDDMHAVSINHPVSLFFDEPGWLCFLDDIMPSG
ASRRYWLKYLDIADLSLDEQNFILLKFGTIAPVGNLRVKESLPERSVIADRLTFTVDDVKNRAADFLDYAQYRGAAAGGA
TGAGGEAPKLLLRCDDEQNIWIDSYQDDQQNRDLHYLVKYPRGSRSPVDCDILRAEYHYYHELAEMGFETIPTANMRLEE
GHSYPSLWLPRFDIYFNELGQQRYAMESVYSILGKAAGVTLDHEQTIRTLVHKITHSHMVLEQGYQFDIQAFVLEWVQRD
LLNILFGNSDNHGRNTAFLKGDGWIKLAPIYDFAPMKADPEGVARTTKWQAPLEVGGEYDFQGIADSLADLVPAQELMAA
LKLTARQCLNLKQRLIARGVPERIIDMPAIGFTYIEDKLTRWGLV

Download         Length: 1338 bp

>T38943 NZ_AP024613:c4351062-4349725 [Shewanella algae]
ATGGAACATTTAACTATTCAGGCTTTTATCAATAGCCAATGGATAGATATTGCAAAGCTCTCTTTTCCAAACAGCGAACA
AGGTCATTATCGGCTTACCTCATTAGATTACGAGCAAGATTATGCCCTGGCAGAGCTCAATAAAGACGACATGCATGCCG
TTTCGATAAATCACCCTGTTAGCCTGTTTTTTGATGAGCCGGGGTGGCTTTGTTTCCTCGATGACATCATGCCTAGCGGC
GCAAGTCGCCGCTACTGGCTTAAGTATCTCGATATCGCAGATCTGAGCTTAGATGAGCAAAATTTTATCCTGTTAAAGTT
TGGCACTATCGCTCCGGTAGGTAATTTGCGGGTCAAGGAATCATTGCCTGAGCGCTCAGTCATTGCTGACAGGCTGACAT
TCACCGTGGATGACGTTAAAAATCGCGCGGCTGATTTTCTGGATTACGCACAATACCGAGGCGCTGCTGCTGGTGGTGCA
ACAGGAGCAGGCGGGGAAGCGCCCAAGTTGCTGTTACGTTGTGACGATGAGCAAAACATCTGGATTGATAGCTATCAGGA
CGACCAACAAAACCGAGACCTGCATTATTTGGTGAAATACCCAAGAGGCTCACGTTCACCCGTTGATTGTGACATCTTGC
GAGCAGAGTACCACTATTACCACGAGCTGGCAGAAATGGGCTTTGAGACTATTCCAACGGCCAATATGCGACTCGAAGAG
GGCCATTCCTACCCATCATTGTGGCTGCCGCGTTTTGATATTTATTTCAATGAACTTGGCCAGCAGCGTTACGCGATGGA
ATCGGTTTACTCGATACTGGGTAAAGCTGCCGGAGTTACCTTAGATCATGAGCAAACCATAAGAACGCTCGTCCACAAGA
TCACTCATAGCCATATGGTCTTAGAGCAAGGTTATCAGTTTGATATTCAGGCTTTTGTGCTTGAGTGGGTTCAGAGAGAC
TTACTCAATATCCTATTTGGTAACAGTGATAACCACGGGCGTAATACCGCATTTCTTAAAGGTGATGGTTGGATAAAGCT
TGCCCCTATCTATGACTTTGCACCAATGAAGGCTGATCCTGAAGGGGTGGCCAGAACCACAAAGTGGCAAGCACCGCTCG
AAGTTGGGGGTGAGTATGACTTTCAAGGTATTGCCGATTCGTTGGCCGATTTGGTGCCTGCTCAAGAGTTAATGGCAGCA
TTAAAGCTCACCGCCCGGCAATGTCTTAACTTGAAGCAGCGCTTAATTGCGCGTGGTGTACCGGAACGGATTATCGATAT
GCCTGCGATTGGCTTTACTTATATCGAAGACAAGCTAACAAGGTGGGGATTGGTATGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16665.99 Da        Isoelectric Point: 10.5046

>AT38943 WP_208147841.1 NZ_AP024613:c4349728-4349273 [Shewanella algae]
MSDKTSTLESAKEAIARLRANRRQAGDVAIEASQYQLSLDAEETHAKQAPPPQRASKHSGRVSTVERRKAIEGVTQRLLR
GELTQGQALKALRIEVLGLTQDEYANLAKVSRKTLSDVENDRGSYKTDILDRLFKPFGLRVGIVPISIGIK

Download         Length: 456 bp

>AT38943 NZ_AP024613:c4349728-4349273 [Shewanella algae]
ATGAGTGATAAAACATCTACCCTTGAGTCTGCTAAAGAGGCTATTGCTCGTCTTAGAGCCAATCGTCGGCAAGCTGGTGA
TGTTGCAATTGAAGCGTCACAATATCAGCTCTCACTAGACGCTGAAGAGACTCACGCAAAGCAAGCTCCCCCTCCCCAAC
GTGCTTCCAAGCATAGCGGGAGGGTGAGTACTGTTGAGAGACGTAAGGCCATCGAAGGCGTTACCCAAAGGCTATTACGC
GGAGAACTTACTCAAGGGCAAGCTCTTAAAGCTTTACGTATTGAGGTTTTAGGCCTAACCCAAGACGAGTATGCAAATTT
GGCTAAAGTGTCACGTAAGACCCTCTCTGACGTTGAGAACGATCGGGGTAGCTATAAGACTGATATTCTCGATCGATTGT
TTAAACCCTTTGGCCTGAGAGTGGGGATTGTGCCTATCTCTATCGGCATCAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References