Detailed information of TA system TA038943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4349273..4351062
• Replicon: chromosome
• Accession: NZ_AP024613
• Organism: Shewanella algae strain TUM17379

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K5628_RS19440
• Protein ID: WP_208139384.1
• Coordinates: 4349725..4351062 (-)
• Length: 446 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K5628_RS19435
• Protein ID: WP_208147841.1
• Coordinates: 4349273..4349728 (-)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5628_RS19420 (TUM17379_38340)	4346697..4346972	-	276	WP_208147838.1	hypothetical protein	-
K5628_RS19425 (TUM17379_38350)	4347180..4347698	-	519	WP_123117050.1	ankyrin repeat domain-containing protein	-
K5628_RS19430 (TUM17379_38360)	4347704..4348912	-	1209	WP_208147839.1	GH-E family nuclease	-
K5628_RS19435 (TUM17379_38370)	4349273..4349728	-	456	WP_208147841.1	helix-turn-helix domain-containing protein	Antitoxin
K5628_RS19440 (TUM17379_38380)	4349725..4351062	-	1338	WP_208139384.1	HipA domain-containing protein	Toxin
K5628_RS19445 (TUM17379_38390)	4351223..4352434	-	1212	WP_107005245.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (163-397)

Antitoxin

• Cro/C1-type helix-turn-helix domain (86-141)

Sequences

Toxin

Protein

• Length: 446 a.a.
• Molecular weight: 50739.46 Da
• Isoelectric Point: 4.7687

>T38943 WP_208139384.1 NZ_AP024613:c4351062-4349725 [Shewanella algae]
MEHLTIQAFINSQWIDIAKLSFPNSEQGHYRLTSLDYEQDYALAELNKDDMHAVSINHPVSLFFDEPGWLCFLDDIMPSG
ASRRYWLKYLDIADLSLDEQNFILLKFGTIAPVGNLRVKESLPERSVIADRLTFTVDDVKNRAADFLDYAQYRGAAAGGA
TGAGGEAPKLLLRCDDEQNIWIDSYQDDQQNRDLHYLVKYPRGSRSPVDCDILRAEYHYYHELAEMGFETIPTANMRLEE
GHSYPSLWLPRFDIYFNELGQQRYAMESVYSILGKAAGVTLDHEQTIRTLVHKITHSHMVLEQGYQFDIQAFVLEWVQRD
LLNILFGNSDNHGRNTAFLKGDGWIKLAPIYDFAPMKADPEGVARTTKWQAPLEVGGEYDFQGIADSLADLVPAQELMAA
LKLTARQCLNLKQRLIARGVPERIIDMPAIGFTYIEDKLTRWGLV

Nucleotide

• Length: 1338 bp

>T38943 NZ_AP024613:c4351062-4349725 [Shewanella algae]
ATGGAACATTTAACTATTCAGGCTTTTATCAATAGCCAATGGATAGATATTGCAAAGCTCTCTTTTCCAAACAGCGAACA
AGGTCATTATCGGCTTACCTCATTAGATTACGAGCAAGATTATGCCCTGGCAGAGCTCAATAAAGACGACATGCATGCCG
TTTCGATAAATCACCCTGTTAGCCTGTTTTTTGATGAGCCGGGGTGGCTTTGTTTCCTCGATGACATCATGCCTAGCGGC
GCAAGTCGCCGCTACTGGCTTAAGTATCTCGATATCGCAGATCTGAGCTTAGATGAGCAAAATTTTATCCTGTTAAAGTT
TGGCACTATCGCTCCGGTAGGTAATTTGCGGGTCAAGGAATCATTGCCTGAGCGCTCAGTCATTGCTGACAGGCTGACAT
TCACCGTGGATGACGTTAAAAATCGCGCGGCTGATTTTCTGGATTACGCACAATACCGAGGCGCTGCTGCTGGTGGTGCA
ACAGGAGCAGGCGGGGAAGCGCCCAAGTTGCTGTTACGTTGTGACGATGAGCAAAACATCTGGATTGATAGCTATCAGGA
CGACCAACAAAACCGAGACCTGCATTATTTGGTGAAATACCCAAGAGGCTCACGTTCACCCGTTGATTGTGACATCTTGC
GAGCAGAGTACCACTATTACCACGAGCTGGCAGAAATGGGCTTTGAGACTATTCCAACGGCCAATATGCGACTCGAAGAG
GGCCATTCCTACCCATCATTGTGGCTGCCGCGTTTTGATATTTATTTCAATGAACTTGGCCAGCAGCGTTACGCGATGGA
ATCGGTTTACTCGATACTGGGTAAAGCTGCCGGAGTTACCTTAGATCATGAGCAAACCATAAGAACGCTCGTCCACAAGA
TCACTCATAGCCATATGGTCTTAGAGCAAGGTTATCAGTTTGATATTCAGGCTTTTGTGCTTGAGTGGGTTCAGAGAGAC
TTACTCAATATCCTATTTGGTAACAGTGATAACCACGGGCGTAATACCGCATTTCTTAAAGGTGATGGTTGGATAAAGCT
TGCCCCTATCTATGACTTTGCACCAATGAAGGCTGATCCTGAAGGGGTGGCCAGAACCACAAAGTGGCAAGCACCGCTCG
AAGTTGGGGGTGAGTATGACTTTCAAGGTATTGCCGATTCGTTGGCCGATTTGGTGCCTGCTCAAGAGTTAATGGCAGCA
TTAAAGCTCACCGCCCGGCAATGTCTTAACTTGAAGCAGCGCTTAATTGCGCGTGGTGTACCGGAACGGATTATCGATAT
GCCTGCGATTGGCTTTACTTATATCGAAGACAAGCTAACAAGGTGGGGATTGGTATGA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 16665.99 Da
• Isoelectric Point: 10.5046

>AT38943 WP_208147841.1 NZ_AP024613:c4349728-4349273 [Shewanella algae]
MSDKTSTLESAKEAIARLRANRRQAGDVAIEASQYQLSLDAEETHAKQAPPPQRASKHSGRVSTVERRKAIEGVTQRLLR
GELTQGQALKALRIEVLGLTQDEYANLAKVSRKTLSDVENDRGSYKTDILDRLFKPFGLRVGIVPISIGIK

Nucleotide

• Length: 456 bp

>AT38943 NZ_AP024613:c4349728-4349273 [Shewanella algae]
ATGAGTGATAAAACATCTACCCTTGAGTCTGCTAAAGAGGCTATTGCTCGTCTTAGAGCCAATCGTCGGCAAGCTGGTGA
TGTTGCAATTGAAGCGTCACAATATCAGCTCTCACTAGACGCTGAAGAGACTCACGCAAAGCAAGCTCCCCCTCCCCAAC
GTGCTTCCAAGCATAGCGGGAGGGTGAGTACTGTTGAGAGACGTAAGGCCATCGAAGGCGTTACCCAAAGGCTATTACGC
GGAGAACTTACTCAAGGGCAAGCTCTTAAAGCTTTACGTATTGAGGTTTTAGGCCTAACCCAAGACGAGTATGCAAATTT
GGCTAAAGTGTCACGTAAGACCCTCTCTGACGTTGAGAACGATCGGGGTAGCTATAAGACTGATATTCTCGATCGATTGT
TTAAACCCTTTGGCCTGAGAGTGGGGATTGTGCCTATCTCTATCGGCATCAAATAG