Detailed information of TA system TA038942

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3496107..3496749
• Replicon: chromosome
• Accession: NZ_AP024613
• Organism: Shewanella algae strain TUM17379

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: -
• Locus tag: K5628_RS15615
• Protein ID: WP_123116740.1
• Coordinates: 3496107..3496529 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5628_RS15620
• Protein ID: WP_028779782.1
• Coordinates: 3496510..3496749 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5628_RS15590 (TUM17379_30760)	3491624..3492103	-	480	WP_071238276.1	SoxR reducing system RseC family protein	-
K5628_RS15595 (TUM17379_30770)	3492114..3493046	-	933	WP_025887844.1	MucB/RseB C-terminal domain-containing protein	-
K5628_RS15600 (TUM17379_30780)	3493056..3493676	-	621	WP_123116739.1	RseA family anti-sigma factor	-
K5628_RS15605 (TUM17379_30790)	3493701..3494279	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5628_RS15610 (TUM17379_30800)	3494479..3496089	+	1611	WP_025010550.1	L-aspartate oxidase	-
K5628_RS15615 (TUM17379_30810)	3496107..3496529	-	423	WP_123116740.1	protein YgfX	Toxin
K5628_RS15620 (TUM17379_30820)	3496510..3496749	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5628_RS15625 (TUM17379_30830)	3496848..3497756	-	909	WP_025010548.1	transcriptional activator NhaR	-
K5628_RS15630 (TUM17379_30840)	3497773..3498156	-	384	WP_062793820.1	hypothetical protein	-
K5628_RS15635 (TUM17379_30850)	3498153..3499328	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5628_RS15640 (TUM17379_30860)	3499445..3500239	-	795	WP_208147439.1	thymidylate synthase	-
K5628_RS15645 (TUM17379_30870)	3500239..3501066	-	828	WP_123116742.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16368.93 Da
• Isoelectric Point: 7.5553

>T38942 WP_123116740.1 NZ_AP024613:c3496529-3496107 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSRFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38942 NZ_AP024613:c3496529-3496107 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCGCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38942 WP_028779782.1 NZ_AP024613:c3496749-3496510 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38942 NZ_AP024613:c3496749-3496510 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1