38939

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4136080..4137620 Replicon chromosome
Accession NZ_AP024612
Organism Shewanella algae strain TUM17378

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5624_RS18455 Protein ID WP_144380005.1
Coordinates 4136080..4137381 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5624_RS18460 Protein ID WP_123116962.1
Coordinates 4137384..4137620 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5624_RS18425 (TUM17378_35970) 4131315..4131590 + 276 WP_045283442.1 hypothetical protein -
K5624_RS18430 (TUM17378_35980) 4131640..4132074 + 435 WP_020442396.1 HNH endonuclease -
K5624_RS18435 (TUM17378_35990) 4132413..4132760 + 348 WP_025011793.1 hypothetical protein -
K5624_RS18440 (TUM17378_36000) 4133162..4134325 + 1164 WP_144380008.1 RNA ligase RtcB family protein -
K5624_RS18445 (TUM17378_36010) 4134325..4134960 + 636 WP_144380007.1 peptide chain release factor H -
K5624_RS18450 (TUM17378_36020) 4135066..4136019 - 954 WP_144163947.1 tetratricopeptide repeat protein -
K5624_RS18455 (TUM17378_36030) 4136080..4137381 - 1302 WP_144380005.1 HipA domain-containing protein Toxin
K5624_RS18460 (TUM17378_36040) 4137384..4137620 - 237 WP_123116962.1 helix-turn-helix domain-containing protein Antitoxin
K5624_RS18465 (TUM17378_36050) 4137829..4138515 - 687 WP_144380004.1 cold shock domain-containing protein -
K5624_RS18470 4139344..4139718 + 375 WP_144380003.1 molecular chaperone DnaJ -
K5624_RS18475 (TUM17378_36060) 4139750..4140535 + 786 WP_144380002.1 NYN domain-containing protein -
K5624_RS18480 (TUM17378_36070) 4140643..4142205 + 1563 WP_144380001.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48542.32 Da        Isoelectric Point: 4.7921

>T38939 WP_144380005.1 NZ_AP024612:c4137381-4136080 [Shewanella algae]
MSGAANLVLDMHLGDRIIGDLSFDPATESFAVSYSQDWRQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEDPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKAIAMNVANVEVRHFGRHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCTNPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLNGLD
NDEQAFVASYKAQLLTRCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T38939 NZ_AP024612:c4137381-4136080 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGATTTGTCATTCGATCCCGCTAC
TGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCGGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGCTTGGATTATCTCATCGAATCT
CTTGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATAGGCTTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTGCGCCTGGAAGATCCTGAGC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTGTTCTACAAC
GGTAAGCAATTTGGTTTCGGTGAAGGTGCCTTATCATCGACCCATATCTTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGGCGATAGCCATGAATGTCGCGAATGTTGAGGTCCGCCATTTTGGTCGGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCTGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGTGTTAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCACTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCCTGTATGAAGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCGTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACGAGAATAAGCCAAGAAATAGACGGTGTTATCGCAATGCTCAATGGATTGGAT
AACGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGACAAGGTGTGAGCGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8491.01 Da        Isoelectric Point: 9.6887

>AT38939 WP_123116962.1 NZ_AP024612:c4137620-4137384 [Shewanella algae]
MASTLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIRLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT38939 NZ_AP024612:c4137620-4137384 [Shewanella algae]
ATGGCCTCCACATTAACTCCACATTCATTGGGCGCTTTAATTAAGGCCCGTAGAAAAGAAGCTGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGTTTGGGGATCCGTCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References