38936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 788936..790485 Replicon chromosome
Accession NZ_AP024612
Organism Shewanella algae strain TUM17378

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5624_RS03635 Protein ID WP_144166193.1
Coordinates 788936..790237 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5624_RS03640 Protein ID WP_025011264.1
Coordinates 790237..790485 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5624_RS03620 (TUM17378_07010) 784435..785019 + 585 WP_028781108.1 LysE family translocator -
K5624_RS03625 (TUM17378_07020) 785097..787124 - 2028 WP_093982364.1 S9 family peptidase -
K5624_RS03630 (TUM17378_07030) 787428..788795 + 1368 WP_028781110.1 L-cystine transporter -
K5624_RS03635 (TUM17378_07040) 788936..790237 - 1302 WP_144166193.1 type II toxin-antitoxin system HipA family toxin Toxin
K5624_RS03640 (TUM17378_07050) 790237..790485 - 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5624_RS03645 (TUM17378_07060) 790997..792688 + 1692 WP_144224924.1 ATP-binding cassette domain-containing protein -
K5624_RS03650 (TUM17378_07070) 792701..793075 - 375 WP_014386412.1 PH domain-containing protein -
K5624_RS03655 (TUM17378_07080) 793086..795011 - 1926 WP_144128793.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48638.33 Da        Isoelectric Point: 9.1907

>T38936 WP_144166193.1 NZ_AP024612:c790237-788936 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYR
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQASATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIEQIMKLLMGSSNALEDQYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPEHISNSIFENANKIIKKI

Download         Length: 1302 bp

>T38936 NZ_AP024612:c790237-788936 [Shewanella algae]
ATGCAAAAGCTAATAGCATACATGAATGGTGAACTTGTTGGCACCTTGGCGAAGCATAAGAACGGCGCTCACACTTTTCA
ATATGATAAGGACTGGATAACCAATGCAATGGCTCGCCCACTGTCATTGTCTTTGAGGCTTCAATTACCGACTATCACTT
CCGATGCCGTTATCAACTATTTTGACAACCTCTTACCAGACAGCCCACAAGTCAGAGATAGGATCGTTGCAAGGTACAGA
GCCTCGTCCAAACAACCATTTGATCTCTTGAAAGAAATTGGAAAGGATAGTGTTGGTGCTATTGCACTATTTCCTCCCGA
ACACCCCTATAAAAAAGAGCCACTCAGCTACGAAATATTGGATAACAAGAAACTAGAAGCCGTTCTTTCTGCATACAAGT
CTGATATTCCCCTCGGAATGCTCAAAGAGGAAGAAGACTTTAGGATCTCAGTGGCAGGTGCTCAAGAAAAAACCGCACTC
TTATTCATTGATGGACAATGGTGTATACCGAAAGGAAACACCCCAACCACTCACATTATCAAGCTGCCAATAGGCGAAAT
ACCACAAGCTAGCGCGACACTGGATCTCAAAGATAGCGTAGAAAATGAATATCTTTGCATTGAGCTAGCTAAAGCGCTGG
GATTCGCAGTTCCCAGCGTCAATATAATCAAAACAGACAACCTTAAAGCTTTAGCTGTAGAACGATTTGATCGACGCTGG
ACAAAAGACAGAGCAGGCTTGCTACGCTTACCTCAAGAAGATATTTGCCAAGTGTTTGGTATGCCATCATCCATCAAATA
TGAATCTCAAGGTGGTCCAGGCATAGAACAGATCATGAAGTTACTAATGGGCTCAAGTAATGCACTTGAAGATCAATATA
ACTTCATGAGATTCCAGGTATTTCAATGGATCATTGGGGCTACGGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AGAGGAGGTAGCTATCGACTCACTCCATTCTACGACATTCTTTCAGCCTACCCATTACTGGGAGGAAAAGGACTCAATAT
TAGACAACTTAAGCTCGCAATGGGGTTAAAAGCCACAAAAGGCAAGAAGTATGAAATCAATAAAATCCTGCCTCGTCACT
TTTTAGATACTGCTAAAGCTGTGAATTTTAGTCAGGATAAGATGCAAAGAATAATGGATGAAATGAAAGGTGCGTTACCT
GAGGCAATCTCGCAAGTAAGGGCGAATCTACCGGAGGGCTTTCCAGAGCATATCTCCAACTCAATTTTTGAGAATGCCAA
CAAAATAATTAAAAAAATCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT38936 WP_025011264.1 NZ_AP024612:c790485-790237 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT38936 NZ_AP024612:c790485-790237 [Shewanella algae]
ATGATATATAGTCCAAAGCAACTCGCAGATATGATGCTACTGATACGCCAAAAGAATGGCTGGACTCAGTCAGAGTTGGC
GAAAAAAGTCGGTATAAAGCAAGCAACAATCTCGAACTTCGAGAACAACCCCAACAAAACAACGCTTTCTACCTTCTTTA
AGCTTGTACAAGCGATGGATCTAACACTGAGTATCCAAGAAAAAACACAGCTGACTTCGCCAAGTGAAAATGATGATGAG
AGTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References