Detailed information of TA system TA038935

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3447703..3448345
• Replicon: chromosome
• Accession: NZ_AP024610
• Organism: Shewanella algae strain TUM4442

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0A5N5U1D5
• Locus tag: K5626_RS15330
• Protein ID: WP_025010549.1
• Coordinates: 3447703..3448125 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A7X5Z2N1
• Locus tag: K5626_RS15335
• Protein ID: WP_028779782.1
• Coordinates: 3448106..3448345 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5626_RS15305 (TUM4442_30060)	3443220..3443699	-	480	WP_144132571.1	SoxR reducing system RseC family protein	-
K5626_RS15310 (TUM4442_30070)	3443710..3444642	-	933	WP_025010553.1	MucB/RseB C-terminal domain-containing protein	-
K5626_RS15315 (TUM4442_30080)	3444652..3445272	-	621	WP_107110666.1	RseA family anti-sigma factor	-
K5626_RS15320 (TUM4442_30090)	3445297..3445875	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
K5626_RS15325 (TUM4442_30100)	3446075..3447685	+	1611	WP_025010550.1	L-aspartate oxidase	-
K5626_RS15330 (TUM4442_30110)	3447703..3448125	-	423	WP_025010549.1	protein YgfX	Toxin
K5626_RS15335 (TUM4442_30120)	3448106..3448345	-	240	WP_028779782.1	succinate dehydrogenase assembly factor 2	Antitoxin
K5626_RS15340 (TUM4442_30130)	3448444..3449352	-	909	WP_025010548.1	transcriptional activator NhaR	-
K5626_RS15345 (TUM4442_30140)	3449369..3449752	-	384	WP_037474378.1	hypothetical protein	-
K5626_RS15350 (TUM4442_30150)	3449749..3450924	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
K5626_RS15355 (TUM4442_30160)	3451041..3451835	-	795	WP_144380182.1	thymidylate synthase	-
K5626_RS15360 (TUM4442_30170)	3451835..3452662	-	828	WP_221052223.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16309.86 Da
• Isoelectric Point: 7.0359

>T38935 WP_025010549.1 NZ_AP024610:c3448125-3447703 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T38935 NZ_AP024610:c3448125-3447703 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9247.74 Da
• Isoelectric Point: 5.0633

>AT38935 WP_028779782.1 NZ_AP024610:c3448345-3448106 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCPDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT38935 NZ_AP024610:c3448345-3448106 [Shewanella algae]
ATGAGTACCCCCAGAGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTATTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z2N1